Chih-Yung Chiu1, Chih-Jung Chen2, Kin-Sun Wong3, Ming-Han Tsai4, Cheng-Hsun Chiu2, Yhu-Chering Huang5. 1. Department of Pediatrics, Chang Gung Memorial Hospital, Keelung, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Division of Pediatric Pulmonology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan. 2. Division of Pediatric Infectious Diseases, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan. 3. Division of Pediatric Pulmonology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan. 4. Department of Pediatrics, Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Pediatric Infectious Diseases, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan. 5. Division of Pediatric Infectious Diseases, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address: ychuang@adm.cgmh.org.tw.
Abstract
BACKGROUND/ PURPOSE: Coinfection of Mycoplasma pneumoniae is not uncommon in children with respiratory syndromes. The purpose of this study was to investigate the impact of bacterial and viral coinfection on mycoplasmal pneumonia in hospitalized children with community-acquired pneumonia (CAP). METHODS: Children coinfected with M. pneumoniae in a prospective study of the etiology of CAP at a tertiary pediatric facility Children's Hospital were enrolled and retrospectively reviewed. The data of clinical characteristics, complications, and outcomes of these children were collected and analyzed. RESULTS: A total of 59 children were enrolled and stratified into three groups: M. pneumoniae infection alone (n = 31), M. pneumoniae with Streptococcus pneumoniae coinfection (n = 9), and M. pneumoniae with virus coinfection (n = 19). As compared with children infected with M. pneumoniae alone, coinfection of children with S. pneumoniae was more likely to occur under the age of 5 years with a longer duration of fever and hospital stay. Furthermore, total leukocyte count and serum C-reactive protein level were also significantly higher in these children (p < 0.01). However, no significant difference in clinical characteristics, complications, and outcomes was observed between the patients infected with either M. pneumoniae alone or with virus coinfection. CONCLUSION: In children with CAP, the influence on the clinical outcomes of M. pneumoniae infection may be heavily dependent on the coinfected pathogen. A potential coexistence of M. pneumoniae infection should be considered in children with features suggesting typical bacterial pneumonia.
BACKGROUND/ PURPOSE: Coinfection of Mycoplasma pneumoniae is not uncommon in children with respiratory syndromes. The purpose of this study was to investigate the impact of bacterial and viral coinfection on mycoplasmal pneumonia in hospitalized children with community-acquired pneumonia (CAP). METHODS:Children coinfected with M. pneumoniae in a prospective study of the etiology of CAP at a tertiary pediatric facility Children's Hospital were enrolled and retrospectively reviewed. The data of clinical characteristics, complications, and outcomes of these children were collected and analyzed. RESULTS: A total of 59 children were enrolled and stratified into three groups: M. pneumoniae infection alone (n = 31), M. pneumoniae with Streptococcus pneumoniae coinfection (n = 9), and M. pneumoniae with virus coinfection (n = 19). As compared with children infected with M. pneumoniae alone, coinfection of children with S. pneumoniae was more likely to occur under the age of 5 years with a longer duration of fever and hospital stay. Furthermore, total leukocyte count and serum C-reactive protein level were also significantly higher in these children (p < 0.01). However, no significant difference in clinical characteristics, complications, and outcomes was observed between the patients infected with either M. pneumoniae alone or with virus coinfection. CONCLUSION: In children with CAP, the influence on the clinical outcomes of M. pneumoniae infection may be heavily dependent on the coinfected pathogen. A potential coexistence of M. pneumoniae infection should be considered in children with features suggesting typical bacterial pneumonia.
Authors: Zheng Jie Marc Ho; Xiahong Zhao; Alex R Cook; Jin Phang Loh; Sock Hoon Ng; Boon Huan Tan; Vernon J Lee Journal: Influenza Other Respir Viruses Date: 2015-07 Impact factor: 4.380
Authors: Maureen H Diaz; Kristen E Cross; Alvaro J Benitez; Lauri A Hicks; Preeta Kutty; Anna M Bramley; James D Chappell; Weston Hymas; Anami Patel; Chao Qi; Derek J Williams; Sandra R Arnold; Krow Ampofo; Wesley H Self; Carlos G Grijalva; Evan J Anderson; Jonathan A McCullers; Andrew T Pavia; Richard G Wunderink; Kathryn M Edwards; Seema Jain; Jonas M Winchell Journal: Open Forum Infect Dis Date: 2016-03-30 Impact factor: 3.835