Literature DB >> 2392680

Slow mortality rate accelerations during aging in some animals approximate that of humans.

C E Finch1, M C Pike, M Witten.   

Abstract

A general measure of the rate of senescence is the acceleration of mortality rate, represented here by the time required for the mortality rate to double (MRD). Rhesus monkeys have an MRD close to that of humans, about 8 years; their shorter life-span results mainly from higher mortality at all ages. In contrast, some groups with short life-spans (rodents and galliform birds) have shorter MRDs and faster senescence. On the basis of the Gompertz mortality rate model, one may estimate the MRD from the maximum life-span (tmax) and the overall population mortality rate. Such calculations show that certain birds have MRDs that are as long as that of humans. These results show that high overall mortality rates or small body sizes do not preclude slow rates of senescence.

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Year:  1990        PMID: 2392680     DOI: 10.1126/science.2392680

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  45 in total

Review 1.  Adult neurogenesis in mammals: an identity crisis.

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Journal:  J Neurosci       Date:  2002-02-01       Impact factor: 6.167

2.  On the beginning of mortality acceleration.

Authors:  Giambattista Salinari; Gustavo De Santis
Journal:  Demography       Date:  2015-02

3.  Mortality and fertility rates in humans and chimpanzees: How within-species variation complicates cross-species comparisons.

Authors:  Kristen Hawkes; Ken R Smith; Shannen L Robson
Journal:  Am J Hum Biol       Date:  2009 Jul-Aug       Impact factor: 1.937

4.  Different Mechanisms of Longevity in Long-Lived Mouse and Caenorhabditis elegans Mutants Revealed by Statistical Analysis of Mortality Rates.

Authors:  Bryan G Hughes; Siegfried Hekimi
Journal:  Genetics       Date:  2016-09-16       Impact factor: 4.562

5.  Evidence for only two independent pathways for decreasing senescence in Caenorhabditis elegans.

Authors:  Kelvin Yen; Charles V Mobbs
Journal:  Age (Dordr)       Date:  2009-08-07

6.  Ever since Gompertz.

Authors:  S J Olshansky; B A Carnes
Journal:  Demography       Date:  1997-02

7.  Actuarial senescence in a long-lived orchid challenges our current understanding of ageing.

Authors:  Johan Petter Dahlgren; Fernando Colchero; Owen R Jones; Dag-Inge Øien; Asbjørn Moen; Nina Sletvold
Journal:  Proc Biol Sci       Date:  2016-11-16       Impact factor: 5.349

8.  A comparative assessment of univariate longevity measures using zoological animal records.

Authors:  Jacob A Moorad; Daniel E L Promislow; Nate Flesness; Richard A Miller
Journal:  Aging Cell       Date:  2012-08-12       Impact factor: 9.304

Review 9.  Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition.

Authors:  Caleb E Finch
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-04       Impact factor: 11.205

10.  Chemical regulation of mid- and late-life longevities in Drosophila.

Authors:  Philip McDonald; Brian M Maizi; Robert Arking
Journal:  Exp Gerontol       Date:  2012-10-05       Impact factor: 4.032

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