| Literature DB >> 23926301 |
Paola Bonetti1, Monica Testoni, Marta Scandurra, Maurilio Ponzoni, Roberto Piva, Afua A Mensah, Andrea Rinaldi, Ivo Kwee, Maria Grazia Tibiletti, Javeed Iqbal, Timothy C Greiner, Wing-Chung Chan, Gianluca Gaidano, Miguel A Piris, Franco Cavalli, Emanuele Zucca, Giorgio Inghirami, Francesco Bertoni.
Abstract
Diffuse large B-cell lymphoma (DLBCL) is the most common form of human lymphoma. DLBCL is a heterogeneous disease characterized by different genetic lesions. We herein report the functional characterization of a recurrent gain mapping on chromosome 11q24.3, found in 23% of 166 DLBCL cases analyzed. The transcription factors ETS1 and FLI1, located within the 11q24.3 region, had significantly higher expression in clinical samples carrying the gain. Functional studies on cell lines showed that ETS1 and FLI1 cooperate in sustaining DLBCL proliferation and viability and regulate genes involved in germinal center differentiation. Taken together, these data identify the 11q24.3 gain as a recurrent lesion in DLBCL leading to ETS1 and FLI1 deregulated expression, which can contribute to the pathogenesis of this disease.Entities:
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Year: 2013 PMID： 23926301 DOI： 10.1182/blood-2013-01-475772
Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113