Literature DB >> 23926212

A cross-sectional study of attitudes about the use of genetic testing for clinical care among patients with an alcohol use disorder.

Brittany Strobel1, Lauren McManus, Shirley Leong, Frederic Blow, Valerie Slaymaker, Wade Berrettini, Adam J Gordon, Charles O'Brien, David Oslin.   

Abstract

AIM: Modification and individualization of medical treatments due to genetic testing has the potential to revolutionize healthcare delivery. As evidence mounts that genetic testing may improve treatment decisions for patients with alcohol use disorder (AUD), we explored patient concerns and attitudes toward genetic testing.
METHODS: Subjects of two USA cross-sectional AUD studies were surveyed regarding their attitudes regarding the use of genetic testing for AUD treatment.
RESULTS: Four hundred and fifty-seven participants were surveyed. Overall, subjects showed a high degree of willingness to provide DNA for clinical use and recognized genetics as important to the pathophysiology of a number of disorders including AUD. There were, however, significant concerns expressed related to insurance denial or employment problems.
CONCLUSION: We found that patients enrolled in AUD studies had some concerns about use of genetic testing. The patients in these two samples were, however, willing and knowledgeable about providing DNA samples.

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Year:  2013        PMID: 23926212      PMCID: PMC3799560          DOI: 10.1093/alcalc/agt130

Source DB:  PubMed          Journal:  Alcohol Alcohol        ISSN: 0735-0414            Impact factor:   2.826


  17 in total

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Journal:  Alcohol Clin Exp Res       Date:  1996-10       Impact factor: 3.455

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6.  Efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysis.

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9.  A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients.

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10.  μ-Opioid receptor gene (OPRM1) polymorphism A118G: lack of association in Finnish populations with alcohol dependence or alcohol consumption.

Authors:  Noora Rouvinen-Lagerström; Jari Lahti; Hannu Alho; Leena Kovanen; Mauri Aalto; Timo Partonen; Kaisa Silander; David Sinclair; Katri Räikkönen; Johan G Eriksson; Aarno Palotie; Seppo Koskinen; Sirkku T Saarikoski
Journal:  Alcohol Alcohol       Date:  2013-05-30       Impact factor: 2.826

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  2 in total

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Review 2.  Pharmacogenetic approaches in the treatment of alcohol use disorders: addressing clinical utility and implementation thresholds.

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  2 in total

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