Literature DB >> 2392615

Mechanism of influenza virus transcription inhibition by matrix (M1) protein.

R W Hankins1, K Nagata, A Kato, A Ishihama.   

Abstract

The mechanism by which influenza virus matrix (M1) protein inhibits viral RNA (vRNA) transcription was investigated. Evidence has been generated that M1 protein inhibits the steps of vRNA transcription initiation and reinitiation more effectively than that of RNA chain elongation. The vRNA-associated nucleocapsid protein (NP) appears to be critical for this inhibition, implying that M1 protein binds to the ribonucleoprotein complex (RNP) through NP.

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Year:  1990        PMID： 2392615     DOI： 10.1016/0923-2516(90)90002-z

Source DB:  PubMed          Journal:  Res Virol        ISSN： 0923-2516


  11 in total

1.  Robust kinetics of an RNA virus: Transcription rates are set by genome levels.

Authors:  Collin Timm; Ankur Gupta; John Yin
Journal:  Biotechnol Bioeng       Date:  2015-05-20       Impact factor: 4.530

2.  Modeling the intracellular dynamics of influenza virus replication to understand the control of viral RNA synthesis.

Authors:  Frank S Heldt; Timo Frensing; Udo Reichl
Journal:  J Virol       Date:  2012-05-16       Impact factor: 5.103

3.  Hyperphosphorylation of mutant influenza virus matrix protein, M1, causes its retention in the nucleus.

Authors:  G Whittaker; I Kemler; A Helenius
Journal:  J Virol       Date:  1995-01       Impact factor: 5.103

4.  Growth control of influenza A virus by M1 protein: analysis of transfectant viruses carrying the chimeric M gene.

Authors:  J Yasuda; D J Bucher; A Ishihama
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

5.  Molecular dissection of influenza virus nucleoprotein: deletion mapping of the RNA binding domain.

Authors:  M Kobayashi; T Toyoda; D M Adyshev; Y Azuma; A Ishihama
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

6.  Rabies virus M protein expressed in Escherichia coli and its regulatory role in virion-associated transcriptase activity.

Authors:  Y Ito; A Nishizono; K Mannen; K Hiramatsu; K Mifune
Journal:  Arch Virol       Date:  1996       Impact factor: 2.574

7.  Nuclear retention of M1 protein in a temperature-sensitive mutant of influenza (A/WSN/33) virus does not affect nuclear export of viral ribonucleoproteins.

Authors:  O Rey; D P Nayak
Journal:  J Virol       Date:  1992-10       Impact factor: 5.103

8.  Regulatory effects of matrix protein variations on influenza virus growth.

Authors:  J Yasuda; T Toyoda; M Nakayama; A Ishihama
Journal:  Arch Virol       Date:  1993       Impact factor: 2.574

Review 9.  New aspects of influenza viruses.

Authors:  M W Shaw; N H Arden; H F Maassab
Journal:  Clin Microbiol Rev       Date:  1992-01       Impact factor: 26.132

10.  Multiscale modeling of influenza A virus infection supports the development of direct-acting antivirals.

Authors:  Frank S Heldt; Timo Frensing; Antje Pflugmacher; Robin Gröpler; Britta Peschel; Udo Reichl
Journal:  PLoS Comput Biol       Date:  2013-11-21       Impact factor: 4.475
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