Literature DB >> 23925679

γ-Benzene hexachloride poisoning leading to acute hepatorenal decompensation.

Rudrajit Paul1, Arunansu Talukdar, Raja Bhattacharya, Gouranga Santra.   

Abstract

γ-Benzene hexachloride is a commonly used insecticide of organochlorine group. Notable toxic effects include seizures, ataxia, confusion and other central nervous system dysfunction. A 30-year-old male farmer with suicidal ingestion of γ-benzene hexachloride poison developed acute intrinsic renal failure with azotaemia and diminished urine output along with features of acute fulminate liver failure. Renal function recovered with haemodialysis and liver parameters gradually normalised with time. As per our knowledge simultaneous acute hepatic and kidney injury associated with γ-benzene hexachloride poison is never reported in humans. The exact pathophysiology of this life-threatening complication is an enigma. However, oxidative stress has been postulated as a contributory factor as suggested in animal studies. Conservative management with successful outcome in our case stresses on the impact of watchful observation and aggressive management. He was discharged after 3 weeks at stable condition and was healthy at 3 months follow-up.

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Year:  2013        PMID: 23925679      PMCID: PMC3761783          DOI: 10.1136/bcr-2013-009851

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  5 in total

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Journal:  Toxicol Lett       Date:  1990-09       Impact factor: 4.372

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Authors:  Ashish Goel; Praveen Aggarwal
Journal:  Natl Med J India       Date:  2007 Jul-Aug       Impact factor: 0.537

5.  Benzene hexachloride poisoning with rhabdomyolysis and acute kidney injury.

Authors:  P R Shah; V B Kute; M R Gumber; H V Patel; M P Patel; D K Yadav; A V Vanikar; H L Trivedi
Journal:  Indian J Nephrol       Date:  2013-01
  5 in total
  1 in total

1.  Thoracic empyema and pectoral abscess resulting from attempting suicide by injection of benzene in the pleural cavity.

Authors:  Sjaak Pouwels; Chris Nijdam; Manon L Zwinkels; Marie-Chantal Struijs; Robert Kortekaas
Journal:  Respir Med Case Rep       Date:  2018-04-20
  1 in total

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