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Literature DB >> 23925663

The role of microRNAs in lung cancer progression.

Wen-Cheng Zhang¹, Jinbo Liu, Xiangying Xu, Guangshun Wang.

Abstract

Lung cancer is a heterogeneous disease with currently still unknown mechanisms of development. Besides genetic and epigenetic mechanisms, microRNAs (miRNAs) have recently been discovered as one of the crucial players in lung carcinogenesis through posttranscriptional regulation of tumor suppressor and oncogenes. A substantial number of deregulated miRNAs have been revealed in lung cancer, and the biological significance of those miRNAs has been confirmed in multiple functional experiments. A growing number of studies suggest involvement of miRNAs in various steps of lung carcinogenesis. Great biological stability of miRNAs opens novel fields in biomarker research with potential clinical implementation in screening, diagnosis and prediction of prognosis. In this review, we provide the basic knowledge of miRNA biogenesis and discuss extensively the role of miRNAs in lung carcinogenesis, including potential translational clinical implementations.

Entities: Disease

Mesh：

Substances：

Year: 2013 PMID： 23925663 DOI： 10.1007/s12032-013-0675-8

Source DB: PubMed Journal: Med Oncol ISSN： 1357-0560 Impact factor: 3.064

55 in total

1. MicroRNA-101 exerts tumor-suppressive functions in non-small cell lung cancer through directly targeting enhancer of zeste homolog 2.

Authors: Ji-Guang Zhang; Jian-Feng Guo; Dong-Lei Liu; Quan Liu; Jian-Jun Wang
Journal: J Thorac Oncol Date: 2011-04 Impact factor: 15.609

2. The prognostic impact of microRNA sequence polymorphisms on the recurrence of patients with completely resected non-small cell lung cancer.

Authors: Kyong-Ah Yoon; Hyekyoung Yoon; Sohee Park; Hee-Jin Jang; Jae Ill Zo; Hyun-Sung Lee; Jin Soo Lee
Journal: J Thorac Cardiovasc Surg Date: 2012-07-18 Impact factor: 5.209

3. A functional polymorphism at microRNA-629-binding site in the 3'-untranslated region of NBS1 gene confers an increased risk of lung cancer in Southern and Eastern Chinese population.

Authors: Lei Yang; Yinyan Li; Mei Cheng; Dongsheng Huang; Jian Zheng; Bin Liu; Xiaoxuan Ling; Qingchu Li; Xin Zhang; Weidong Ji; Yifeng Zhou; Jiachun Lu
Journal: Carcinogenesis Date: 2011-11-22 Impact factor: 4.944

4. MiR-365 regulates lung cancer and developmental gene thyroid transcription factor 1.

Authors: Ji Qi; Shawn J Rice; Anna C Salzberg; E Aaron Runkle; Jason Liao; Dani S Zander; David Mu
Journal: Cell Cycle Date: 2012-01-01 Impact factor: 4.534

5. Genetic variants in miR-146a, miR-149, miR-196a2, miR-499 and their influence on relative expression in lung cancers.

Authors: Serena Vinci; Stefania Gelmini; Nicola Pratesi; Simona Conti; Francesca Malentacchi; Lisa Simi; Mario Pazzagli; Claudio Orlando
Journal: Clin Chem Lab Med Date: 2011-09-09 Impact factor: 3.694

6. MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer.

Authors: Mattia Boeri; Carla Verri; Davide Conte; Luca Roz; Piergiorgio Modena; Federica Facchinetti; Elisa Calabrò; Carlo M Croce; Ugo Pastorino; Gabriella Sozzi
Journal: Proc Natl Acad Sci U S A Date: 2011-02-07 Impact factor: 11.205

7. A functional genetic variant in microRNA-196a2 is associated with increased susceptibility of lung cancer in Chinese.

Authors: Tian Tian; Yongqian Shu; Jiaping Chen; Zhibin Hu; Lin Xu; Guangfu Jin; Jie Liang; Ping Liu; Xiaoyi Zhou; Ruifen Miao; Hongxia Ma; Yijiang Chen; Hongbing Shen
Journal: Cancer Epidemiol Biomarkers Prev Date: 2009-03-17 Impact factor: 4.254

8. MicroRNA profiling in lung cancer reveals new molecular markers for diagnosis.

Authors: Charalambos C Solomides; Barry J Evans; Jean-Marc Navenot; Rajanikanth Vadigepalli; Stephen C Peiper; Zi-xuan Wang
Journal: Acta Cytol Date: 2012-11-24 Impact factor: 2.319

9. Large-scale screening identifies a novel microRNA, miR-15a-3p, which induces apoptosis in human cancer cell lines.

Authors: Aliaksandr Druz; Yu-Chi Chen; Rajarshi Guha; Michael Betenbaugh; Scott E Martin; Joseph Shiloach
Journal: RNA Biol Date: 2013-01-25 Impact factor: 4.652

10. MicroRNA-449a is downregulated in non-small cell lung cancer and inhibits migration and invasion by targeting c-Met.

Authors: Wenting Luo; Bo Huang; Zixuan Li; Haiying Li; Limei Sun; Qingfu Zhang; Xueshan Qiu; Enhua Wang
Journal: PLoS One Date: 2013-05-29 Impact factor: 3.240

9 in total

1. MicroRNA-218 inhibits gastrointestinal stromal tumor cell and invasion by targeting KIT.

Authors: Rong Fan; Jie Zhong; Sichang Zheng; Zhengting Wang; Ying Xu; Shuyi Li; Jie Zhou; Fei Yuan
Journal: Tumour Biol Date: 2013-12-29

2. miR-331-3p Inhibits Tumor Cell Proliferation, Metastasis, Invasion by Targeting MLLT10 in Non-Small Cell Lung Cancer.

Authors: Qing-Qing Tian; Jing Xia; Xin Zhang; Bao-Qin Gao; Wei Wang
Journal: Cancer Manag Res Date: 2020-07-14 Impact factor: 3.989

3. miR-411 contributes the cell proliferation of lung cancer by targeting FOXO1.

Authors: Zhiju Zhao; Limei Qin; Shu Li
Journal: Tumour Biol Date: 2015-11-17

4. miR-137 impairs the proliferative and migratory capacity of human non-small cell lung cancer cells by targeting paxillin.

Authors: Yueyang Bi; Yong Han; Haiyang Bi; Fuquan Gao; Xiaozhi Wang
Journal: Hum Cell Date: 2013-11-17 Impact factor: 4.174

5. Effects of miR-132-3p on progress and epithelial mesenchymal transition of non-small cell lung cancer via regulating KLF7.

Authors: Ning Wang; Ye Xu; Qingkui Guo; Chen Zhu; Wen Zhao; Wenliang Qian; Min Zheng
Journal: J Thorac Dis Date: 2021-04 Impact factor: 2.895

6. Prognostic value of the MicroRNA regulators Dicer and Drosha in non-small-cell lung cancer: co-expression of Drosha and miR-126 predicts poor survival.

Authors: Kenneth Lønvik; Sveinung W Sørbye; Marit N Nilsen; Ruth H Paulssen
Journal: BMC Clin Pathol Date: 2014-12-11