Literature DB >> 23925528

An efficient synthetic route to carbocyclic enaminonitriles via Lewis acid catalysed domino-ring-opening-cyclisation (DROC) of donor-acceptor cyclopropanes with malononitrile.

Manas K Ghorai1, Ranadeep Talukdar, Deo Prakash Tiwari.   

Abstract

A highly efficient strategy for the synthesis of functionalised carbocyclic enaminonitriles in excellent yields has been described. The reaction utilises Yb(OTf)3 catalysed C-C bond cleavage and two simultaneous C-C bond formations of donor-acceptor (DA)-cyclopropanes with malononitrile anions in a domino fashion.

Entities:  

Year:  2013        PMID： 23925528     DOI： 10.1039/c3cc44533j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  1 in total

1.  Temperature controlled condensation of nitriles: efficient and convenient synthesis of β-enaminonitriles, 4-aminopyrimidines and 4-amidinopyrimidines in one system.

Authors:  Yinghua Li; Yingzu Zhu; Shiqun Xiang; Weibin Fan; Jiang Jin; Deguang Huang
Journal:  RSC Adv       Date:  2020-02-12       Impact factor: 3.361
  1 in total

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