| Literature DB >> 23924720 |
Jun Yamauchi1, Mariko Sekiguchi, Tomomi Shirai, Mami Yamada, Yoshiko Ishimi.
Abstract
The production of retinol binding protein 4 (RBP4) is higher in adipose tissue in type 2 diabetes. We have found that proteasome subunit beta type 1 (PSMB1) is a transcriptional activator of Rbp4. In the present study, the putative tyrosine phosphorylation site in PSMB1 was mutated to phenylalanine. The mutated form of PSMB1 displayed increased nuclear translocation, resulting in activation of transcription in adipocytes.Entities:
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Year: 2013 PMID： 23924720 DOI： 10.1271/bbb.130290
Source DB: PubMed Journal: Biosci Biotechnol Biochem ISSN： 0916-8451 Impact factor: 2.043