Jun-jie Yu1, Shu-jie Xia. 1. Department of Urology, First People's Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.
Abstract
OBJECTIVE: To discuss the novel biomarkers of microRNAs in prostate cancer. DATA SOURCES: The literatures about microRNAs and prostate cancer cited in this review were obtained mainly from Pubmed published in English from 2004 to 2012. STUDY SELECTION: Original articles regarding the novel role of microRNAs in prostate cancer were selected. RESULTS: MicroRNAs play an important role in prostate cancer such as cell differentiation, proliferation, apoptosis, and invasion. Especially microRNAs correlate with prostate cancer cell epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs), drug sensitivity, cancer microenvironment, energy metabolism, androgen independence transformation, and diagnosis prediction. CONCLUSIONS: MicroRNAs are involved in various aspects of prostate cancer biology. The role of microRNA in the initiation and development of prostate cancer deserves further study.
OBJECTIVE: To discuss the novel biomarkers of microRNAs in prostate cancer. DATA SOURCES: The literatures about microRNAs and prostate cancer cited in this review were obtained mainly from Pubmed published in English from 2004 to 2012. STUDY SELECTION: Original articles regarding the novel role of microRNAs in prostate cancer were selected. RESULTS: MicroRNAs play an important role in prostate cancer such as cell differentiation, proliferation, apoptosis, and invasion. Especially microRNAs correlate with prostate cancer cell epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs), drug sensitivity, cancer microenvironment, energy metabolism, androgen independence transformation, and diagnosis prediction. CONCLUSIONS: MicroRNAs are involved in various aspects of prostate cancer biology. The role of microRNA in the initiation and development of prostate cancer deserves further study.