UNLABELLED: This study is dedicated to investigate the expression patterns of sperm protein 17 (Sp17), melanoma-specific antigen (MAGE)-C1 and New York esophageal squamous cell carcinoma-1 (NY-ESO-1), to explore the correlation between these cancer-testis antigens and clinical parameters, and to evaluate their values in diagnosis and differentiation of hepatocellular carcinoma. METHODS: Immunohistochemical staining was performed in 45 paraffin-embedded hepatocellular carcinoma specimens. 45 normal peripheral hepatic tissues collected from adjacent non-cancerous areas were used as controls. RESULTS: Positive results of immunohistostaining were obtained in 16 (35.6%), 7 (15.6%) and 36 (80.0%) samples using MAGE-C1, NY-ESO-1 and Sp17 antibodies, respectively. The immunoreactivity of Sp17 was also found in 7 (14.0%) control samples. A statistical correlation between the frequency of Sp17 expression and tumor differentiation grade in hepatocellular carcinoma was confirmed. CONCLUSIONS: Sp17 is highly expressed in hepatocellular carcinoma cells. The frequency of Sp17 expression is closely related to the pathologic differentiation in hepatocellular carcinoma.
UNLABELLED: This study is dedicated to investigate the expression patterns of sperm protein 17 (Sp17), melanoma-specific antigen (MAGE)-C1 and New York esophageal squamous cell carcinoma-1 (NY-ESO-1), to explore the correlation between these cancer-testis antigens and clinical parameters, and to evaluate their values in diagnosis and differentiation of hepatocellular carcinoma. METHODS: Immunohistochemical staining was performed in 45 paraffin-embedded hepatocellular carcinoma specimens. 45 normal peripheral hepatic tissues collected from adjacent non-cancerous areas were used as controls. RESULTS: Positive results of immunohistostaining were obtained in 16 (35.6%), 7 (15.6%) and 36 (80.0%) samples using MAGE-C1, NY-ESO-1 and Sp17 antibodies, respectively. The immunoreactivity of Sp17 was also found in 7 (14.0%) control samples. A statistical correlation between the frequency of Sp17 expression and tumor differentiation grade in hepatocellular carcinoma was confirmed. CONCLUSIONS:Sp17 is highly expressed in hepatocellular carcinoma cells. The frequency of Sp17 expression is closely related to the pathologic differentiation in hepatocellular carcinoma.
Authors: K D Lee; H K Chang; Y K Jo; B S Kim; B H Lee; Y W Lee; H K Lee; M H Huh; Y G Min; G C Spagnoli; T H Yu Journal: Anticancer Res Date: 1999 Nov-Dec Impact factor: 2.480
Authors: Fabio Grizzi; Paolo Gaetani; Barbara Franceschini; Antonio Di Ieva; Piergiuseppe Colombo; Giorgia Ceva-Grimaldi; Angelo Bollati; Eldo E Frezza; E Cobos; Riccardo Rodriguez y Baena; Nicola Dioguardi; Maurizio Chiriva-Internati Journal: BMC Cancer Date: 2006-01-26 Impact factor: 4.430
Authors: K Sideras; S J Bots; K Biermann; D Sprengers; W G Polak; J N M IJzermans; R A de Man; Q Pan; S Sleijfer; M J Bruno; J Kwekkeboom Journal: Br J Cancer Date: 2015-06-09 Impact factor: 7.640