| Literature DB >> 23922366 |
Rebecca N Koehler1, Galit Alter, Sodsai Tovanabutra, Elmar Saathoff, Miguel A Arroyo, Anne M Walsh, Eric E Sanders-Buell, Leonard Maboko, Michael Hoelscher, Merlin L Robb, Nelson L Michael, Francine E McCutchan, Jerome H Kim, Gustavo H Kijak.
Abstract
Here we explore the association between killer cell immunoglobulin-like receptor (KIR)/HLA and human immunodeficiency virus type 1 (HIV-1) acquisition with different viral subtypes circulating in East Africa. In the prospective Cohort Development (CODE) cohort (Mbeya, Tanzania), carriers of KIR3DS1 and its putative ligand (HLA-A or HLA-B Bw4-80Ile alleles) showed increased HIV-1 acquisition risk (odds ratio [OR] = 3.46; 95% confidence interval [CI], 1.12-10.63; P = .04) and a trend for enrichment for subtype A and A-containing recombinants (78% vs. 46%; OR = 4.05; 95% CI, .91-28.30; P = .09) at the expense of subtype C (11% vs. 43%; OR = 0.17; 95% CI, .01-.97; P = .08). In vitro, only natural killer cells from KIR3DS1(+)/HLA-Bw4-80Ile(+) healthy donors showed a 2-fold increased capacity to inhibit replication of subtype C vs subtype A viruses (P = .01). These findings suggest the presence of an innate sieve effect and may inform HIV-1 vaccine development.Entities:
Keywords: East Africa; HIV-1; HLA; KIR; innate immunity; sieve effect; subtypes
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Year: 2013 PMID： 23922366 PMCID： PMC3778971 DOI： 10.1093/infdis/jit349
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226