OBJECTIVE: To compare antiphospholipid antibodies in deliveries with and without stillbirth using a multicenter, population-based case-control study of stillbirths and live births. METHODS: Maternal sera were assayed for immunoglobulin (Ig)G and IgM anticardiolipin and anti-β2-glycoprotein-I antibodies. Assays were performed in 582 stillbirth deliveries and 1,547 live birth deliveries. RESULTS: Elevated levels of IgG anticardiolipin and IgG anti-β2-glycoprotein-I antibodies were associated with an approximate threefold increased odds of stillbirth (crude odds ratio [OR] 3.43, 95% confidence interval [CI] 1.79-6.60, 3.8% compared with 1.1% and OR 3.17, 95% CI 1.30-7.72, (1.9% compared with 0.6%, respectively) when all deliveries with stillbirth were compared with all deliveries with live birth. When the subset of stillbirths not associated with fetal anomalies or obstetric complications was compared with term live births, elevated IgG anticardiolipin antibodies were associated with stillbirth (5.0% compared with 1.0%; OR 5.30, 95% CI, 2.39-11.76; IgG anti-β2-glycoprotein-I antibodies (1.9% compared with 0.6%) had an OR of 3.00 (95% CI 1.01-8.90) and IgM anticardiolipin antibodies (6.0% compared with 3.0%) had an OR of 2.03 (95% CI 1.09-3.76). Elevated levels of anticardiolipin and anti-β2-glycoprotein-I antibodies were associated with a threefold to fivefold increased odds of stillbirth. CONCLUSIONS: Our data support consideration of testing for antiphospholipid antibodies in cases of otherwise unexplained stillbirth. LEVEL OF EVIDENCE: II.
OBJECTIVE: To compare antiphospholipid antibodies in deliveries with and without stillbirth using a multicenter, population-based case-control study of stillbirths and live births. METHODS: Maternal sera were assayed for immunoglobulin (Ig)G and IgM anticardiolipin and anti-β2-glycoprotein-I antibodies. Assays were performed in 582 stillbirth deliveries and 1,547 live birth deliveries. RESULTS: Elevated levels of IgG anticardiolipin and IgG anti-β2-glycoprotein-I antibodies were associated with an approximate threefold increased odds of stillbirth (crude odds ratio [OR] 3.43, 95% confidence interval [CI] 1.79-6.60, 3.8% compared with 1.1% and OR 3.17, 95% CI 1.30-7.72, (1.9% compared with 0.6%, respectively) when all deliveries with stillbirth were compared with all deliveries with live birth. When the subset of stillbirths not associated with fetal anomalies or obstetric complications was compared with term live births, elevated IgG anticardiolipin antibodies were associated with stillbirth (5.0% compared with 1.0%; OR 5.30, 95% CI, 2.39-11.76; IgG anti-β2-glycoprotein-I antibodies (1.9% compared with 0.6%) had an OR of 3.00 (95% CI 1.01-8.90) and IgM anticardiolipin antibodies (6.0% compared with 3.0%) had an OR of 2.03 (95% CI 1.09-3.76). Elevated levels of anticardiolipin and anti-β2-glycoprotein-I antibodies were associated with a threefold to fivefold increased odds of stillbirth. CONCLUSIONS: Our data support consideration of testing for antiphospholipid antibodies in cases of otherwise unexplained stillbirth. LEVEL OF EVIDENCE: II.
Authors: Halit Pinar; Matthew A Koch; Hal Hawkins; Josefine Heim-Hall; Carlos R Abramowsky; Vanessa R Thorsten; Marshall W Carpenter; Hong Holly Zhou; Uma M Reddy Journal: Am J Perinatol Date: 2011-08-03 Impact factor: 1.862
Authors: Halit Pinar; Matthew A Koch; Hal Hawkins; Josefine Heim-Hall; Bahig Shehata; Vanessa R Thorsten; Marshall Carpenter; Amy Lowichik; Uma M Reddy Journal: Am J Perinatol Date: 2011-06-29 Impact factor: 1.862
Authors: Donald J Dudley; Robert Goldenberg; Deborah Conway; Robert M Silver; George R Saade; Michael W Varner; Halit Pinar; Donald Coustan; Radek Bukowski; Barbara Stoll; Matthew A Koch; Corette B Parker; Uma M Reddy Journal: Obstet Gynecol Date: 2010-08 Impact factor: 7.661
Authors: A J Wilcox; C R Weinberg; J F O'Connor; D D Baird; J P Schlatterer; R E Canfield; E G Armstrong; B C Nisula Journal: N Engl J Med Date: 1988-07-28 Impact factor: 91.245
Authors: K J Gibbins; S L Mumford; L A Sjaarda; D W Branch; N J Perkins; A Ye; E F Schisterman; R M Silver Journal: Lupus Date: 2018-05-17 Impact factor: 2.911
Authors: Jessica M Page; Amanda A Allshouse; Irina Cassimatis; Marcela C Smid; Erol Arslan; Vanessa Thorsten; Corette Parker; Michael W Varner; Donald J Dudley; George R Saade; Robert L Goldenberg; Barbara J Stoll; Carol J Hogue; Radek Bukowski; Deborah Conway; Halit Pinar; Uma M Reddy; Robert M Silver Journal: Obstet Gynecol Date: 2020-12 Impact factor: 7.623