Literature DB >> 23921442

The contribution of PmrAB to the virulence of a clinical isolate of Escherichia coli.

Douglas M Warner1, Valérie Duval, Stuart B Levy.   

Abstract

Previous data from our laboratory suggest a relationship between increased pmrAB expression and virulence in an Escherichia coli mouse infection model of pyelonephritis. Competitive infections with wild type and pmrAB mutants showed that disruption of pmrAB caused decreased persistence of E. coli within the mouse kidney. These results were confirmed with plasmid-mediated complementation of the pmrAB mutant. Additionally, increased expression of pmrAB from this complementing plasmid in a previously attenuated marA-rob-soxS triple mutant displayed increased bacterial persistence in the infection when compared with the triple mutant alone. These findings suggest a role for this two-component regulatory system in the virulence of E. coli in a murine pyelonephritis model.

Entities:  

Keywords:  E. coli; infection; kidney; pmrAB

Mesh：

Substances：

Year:  2013        PMID： 23921442      PMCID： PMC3906297          DOI： 10.4161/viru.25931

Source DB:  PubMed          Journal:  Virulence        ISSN： 2150-5594            Impact factor:   5.882


  23 in total

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6.  Risk factors associated with acute pyelonephritis in healthy women.

Authors:  Delia Scholes; Thomas M Hooton; Pacita L Roberts; Kalpana Gupta; Ann E Stapleton; Walter E Stamm
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8.  Identification for mar mutants among quinolone-resistant clinical isolates of Escherichia coli.

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