Literature DB >> 23919347

Development of a practical, asymmetric synthesis of the hepatitis C virus protease inhibitor MK-5172.

Jeffrey Kuethe1, Yong-Li Zhong, Nobuyoshi Yasuda, Gregory Beutner, Katherine Linn, Mary Kim, Benjamin Marcune, Spencer Douglas Dreher, Guy Humphrey, Tao Pei.   

Abstract

The development of a practical, asymmetric synthesis of the hepatitis C virus (HCV) protease inhibitor MK-5172 (1), an 18-membered macrocycle, is described.

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Year:  2013        PMID： 23919347     DOI： 10.1021/ol401864t

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  5 in total

1.  Recent advances in the application of ring-closing metathesis for the synthesis of unsaturated nitrogen heterocycles.

Authors:  Emilia J Groso; Corinna S Schindler
Journal:  Synthesis (Stuttg)       Date:  2019-02-08       Impact factor: 3.157

Review 2.  Evolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversification.

Authors:  James J Sahn; Brett A Granger; Stephen F Martin
Journal:  Org Biomol Chem       Date:  2014-08-19       Impact factor: 3.876

3.  Design and Synthesis of P2-P4 Macrocycles Containing a Unique Spirocyclic Proline: A New Class of HCV NS3/4A Inhibitors.

Authors:  Francisco Velázquez; Mariappan Chelliah; Martin Clasby; Zhuyan Guo; John Howe; Randy Miller; Santhosh Neelamkavil; Unmesh Shah; Aileen Soriano; Yan Xia; Srikanth Venkatraman; Samuel Chackalamannil; Ian W Davies
Journal:  ACS Med Chem Lett       Date:  2016-10-17       Impact factor: 4.345

4.  Photoredox Ni-catalyzed peptide C(sp2)-O cross-coupling: from intermolecular reactions to side chain-to-tail macrocyclization.

Authors:  Hyelee Lee; Nicolas C Boyer; Qiaolin Deng; Hai-Young Kim; Tomi K Sawyer; Nunzio Sciammetta
Journal:  Chem Sci       Date:  2019-04-12       Impact factor: 9.825

5.  Minimum target prices for production of direct-acting antivirals and associated diagnostics to combat hepatitis C virus.

Authors:  Nikolien van de Ven; Joe Fortunak; Bryony Simmons; Nathan Ford; Graham S Cooke; Saye Khoo; Andrew Hill
Journal:  Hepatology       Date:  2015-02-09       Impact factor: 17.425
  5 in total

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