Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Pills of PTEN? In and out for tumor suppression.

Literature DB >> 23917528

Pills of PTEN? In and out for tumor suppression.

Antonella Papa¹, Ming Chen, Pier Paolo Pandolfi.

Abstract

The tumor-suppressive activity of PTEN has always been attributed to its endogenous intracellular function. Recently two different groups have demonstrated that PTEN is secreted/exported into the extracellular environment for uptake by recipient cells, and functions as a tumor suppressor in a cell non-autonomous manner.

Entities: Disease Gene

Mesh：

Substances：

Year: 2013 PMID： 23917528 PMCID： PMC3790232 DOI： 10.1038/cr.2013.103

Source DB: PubMed Journal: Cell Res ISSN： 1001-0602 Impact factor: 25.617

12 in total

Review 1. A continuum model for tumour suppression.

Authors: Alice H Berger; Alfred G Knudson; Pier Paolo Pandolfi
Journal: Nature Date: 2011-08-10 Impact factor: 49.962

2. A secreted PTEN phosphatase that enters cells to alter signaling and survival.

Authors: Benjamin D Hopkins; Barry Fine; Nicole Steinbach; Meaghan Dendy; Zachary Rapp; Jacquelyn Shaw; Kyrie Pappas; Jennifer S Yu; Cindy Hodakoski; Sarah Mense; Joshua Klein; Sarah Pegno; Maria-Luisa Sulis; Hannah Goldstein; Benjamin Amendolara; Liang Lei; Matthew Maurer; Jeffrey Bruce; Peter Canoll; Hanina Hibshoosh; Ramon Parsons
Journal: Science Date: 2013-06-06 Impact factor: 47.728

3. The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells.

Authors: Ulrich Putz; Jason Howitt; Anh Doan; Choo-Peng Goh; Ley-Hian Low; John Silke; Seong-Seng Tan
Journal: Sci Signal Date: 2012-09-25 Impact factor: 8.192

Review 4. Mutations of the human PTEN gene.

Authors: D Bonneau; M Longy
Journal: Hum Mutat Date: 2000 Impact factor: 4.878

5. Subtle variations in Pten dose determine cancer susceptibility.

Authors: Andrea Alimonti; Arkaitz Carracedo; John G Clohessy; Lloyd C Trotman; Caterina Nardella; Ainara Egia; Leonardo Salmena; Katia Sampieri; William J Haveman; Edi Brogi; Andrea L Richardson; Jiangwen Zhang; Pier Paolo Pandolfi
Journal: Nat Genet Date: 2010-04-18 Impact factor: 38.330

Pills of PTEN? In and out for tumor suppression.

Review 1. A continuum model for tumour suppression.

2. A secreted PTEN phosphatase that enters cells to alter signaling and survival.

3. The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells.

Review 4. Mutations of the human PTEN gene.

5. Subtle variations in Pten dose determine cancer susceptibility.

Review 6. PTEN loss in the continuum of common cancers, rare syndromes and mouse models.

7. Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner.

Review 8. Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review.

9. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.

10. The lipid phosphatase activity of PTEN is critical for its tumor supressor function.

1. CMTM3 presents a secreted form released via exosomes.

2. Pseudogene PTENP1 functions as a competing endogenous RNA to suppress clear-cell renal cell carcinoma progression.

3. Deciphering therapeutic potential of PEGylated recombinant PTEN-silver nanoclusters ensemble on 3D spheroids.