Literature DB >> 23916742

Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway.

Wei Wu1, Xiao Yu, Xiao-Ping Luo, Shu-Hua Yang, Dong Zheng.   

Abstract

Tetramethylpyrazine is used in the treatment of many neurological diseases because of its neuroprotective effect. Here, we demonstrate that administration of tetramethylpyrazine effectively reverses memory deficits induced by scopolamine. Moreover, tetramethylpyrazine preserves postsynaptic protein synthesis and restores cAMP/PKA/CREB pathway signaling deficits. Our study not only explores the actions of tetramethylpyrazine on synapses, but also provides novel evidence for the possible therapeutic use of tetramethylpyrazine in dementia.
Copyright © 2013 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Memory; Scopolamine; Synapse; Tetramethylpyrazine

Mesh：

Substances：

Year:  2013        PMID： 23916742     DOI： 10.1016/j.bbr.2013.07.052

Source DB:  PubMed          Journal:  Behav Brain Res        ISSN： 0166-4328            Impact factor:   3.332


  22 in total

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Journal:  Mol Neurobiol       Date:  2015-11-28       Impact factor: 5.590

4.  Tetramethylpyrazine Ameliorates Rotenone-Induced Parkinson's Disease in Rats: Involvement of Its Anti-Inflammatory and Anti-Apoptotic Actions.

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Journal:  Mol Neurobiol       Date:  2016-08-11       Impact factor: 5.590

5.  The Tetramethylpyrazine Analogue T-006 Alleviates Cognitive Deficits by Inhibition of Tau Expression and Phosphorylation in Transgenic Mice Modeling Alzheimer's Disease.

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Journal:  Sci Rep       Date:  2015-04-10       Impact factor: 4.379

7.  Tetramethylpyrazine Produces Antidepressant-Like Effects in Mice Through Promotion of BDNF Signaling Pathway.

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Journal:  Int J Neuropsychopharmacol       Date:  2015-01-24       Impact factor: 5.176

8.  Neuroprotective effects of tetramethylpyrazine against dopaminergic neuron injury in a rat model of Parkinson's disease induced by MPTP.

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Review 10.  Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine.

Authors:  Xinhua Zhou; Guozhen Cui; Hisa Hui Ling Tseng; Simon Ming-Yuen Lee; George Pak Heng Leung; Shun Wan Chan; Yiu Wa Kwan; Maggie Pui Man Hoi
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