| Literature DB >> 23916645 |
Li Wang1, Ying Zhang, Maochao Xu, Yingyao Wang, Sujiao Cheng, Alex Liebrecht, Haifeng Qian, Hui Zhang, Xiguang Qi.
Abstract
Vaccinium bracteatum Thunb. (VBT) is a traditional Chinese herbal medicine. The anti-diabetic activity of VBT leaves' polysaccharide (VBTLP) is studied in this paper. The results indicated VBTLP had a dose-dependent decrease on the blood glucose (BG) level, and the time effect of VBTLP on BG level was also significant. The insulin level of high dose group (HDG) was significantly higher (p<0.05) than that of model control (MC) group. Compared to MC, HDG and lose dose group (LDG) had significantly lower (p<0.05) TC and LDL-C levels, however, TG and HDL-C levels are similar. Compared to non-diabetic control (NC), HDG and LDG had similar plasma lipid levels except for higher LDL-C level. Although body weights of LDG and HDG were significant lower (p<0.05) than that of NC from week 2 to week 6, they were similar to that of PC. The results indicate VBTLP possesses a potential hypoglycemic effect in streptozotocin-induced diabetic mice.Entities:
Keywords: Anti-diabetic activity; Polysaccharides; Vaccinium Bracteatum Thunb
Mesh：
Substances：
Year: 2013 PMID： 23916645 DOI： 10.1016/j.ijbiomac.2013.07.028
Source DB: PubMed Journal: Int J Biol Macromol ISSN： 0141-8130 Impact factor: 6.953