Gokalp Oner1, Iptisam Ipek Muderris. 1. Department of Obstetric and Gynecology, Bogazlıyan State Hospital, Yozgat, Turkey. Electronic address: onerg@yahoo.com.
Abstract
OBJECTIVE: To evaluate ovarian reserve in women with familial Mediterranean fever (FMF). STUDY DESIGN: Thirty women with FMF (20-29 years) and thirty healthy controls (20-29 years) were admitted to this study. Basal serum levels of follicle-stimulating hormone (FSH), oestradiol (E2), luteinizing hormone (LH) and inhibin B were measured on cycle day 3. All participants underwent transvaginal ultrasonographic examination on the third day of their menstrual cycle for the determination of ovarian volume (OV) and total antral follicle count (AFC). RESULTS: Women with FMF had significantly higher concentrations of FSH, LH and E2 than healthy controls. Total AFC was significantly lower in women with FMF than in healthy controls. OV was also lower in the FMF group but there was no statistically significant difference in OV between the groups. Age was negatively associated with FSH and LH. Inhibin B was found to be negatively correlated with LH and OV. CONCLUSIONS: In this preliminary study, the first in FMF patients, we found that ovarian reserve was reduced in women with FMF compared with healthy controls. FMF may affect the ovarian reserve but the mechanism of this effect is unclear.
OBJECTIVE: To evaluate ovarian reserve in women with familial Mediterranean fever (FMF). STUDY DESIGN: Thirty women with FMF (20-29 years) and thirty healthy controls (20-29 years) were admitted to this study. Basal serum levels of follicle-stimulating hormone (FSH), oestradiol (E2), luteinizing hormone (LH) and inhibin B were measured on cycle day 3. All participants underwent transvaginal ultrasonographic examination on the third day of their menstrual cycle for the determination of ovarian volume (OV) and total antral follicle count (AFC). RESULTS:Women with FMF had significantly higher concentrations of FSH, LH and E2 than healthy controls. Total AFC was significantly lower in women with FMF than in healthy controls. OV was also lower in the FMF group but there was no statistically significant difference in OV between the groups. Age was negatively associated with FSH and LH. Inhibin B was found to be negatively correlated with LH and OV. CONCLUSIONS: In this preliminary study, the first in FMFpatients, we found that ovarian reserve was reduced in women with FMF compared with healthy controls. FMF may affect the ovarian reserve but the mechanism of this effect is unclear.
Authors: Ali Şahin; Savaş Karakuş; Yunus Durmaz; Çağlar Yıldız; Hüseyin Aydın; Ahmet Kıvanç Cengiz; Duygu Güler Journal: Int J Rheumatol Date: 2015-05-12