| Literature DB >> 23915114 |
Byungjoon Kang1, Zhenqian Fu, Soon Hyeok Hong.
Abstract
A completely atom-economical and redox-neutral catalytic amide synthesis from an alcohol and a nitrile is realized. The amide C-N bond is efficiently formed between the nitrogen atom of nitrile and the α-carbon of alcohol, with the help of an N-heterocyclic carbene-based ruthenium catalyst, without a single byproduct. A utility of the reaction was demonstrated by synthesizing (13)C or (15)N isotope-labeled amides without involvement of any separate reduction and oxidation step.Entities:
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Year: 2013 PMID： 23915114 DOI： 10.1021/ja404695t
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419