Literature DB >> 23914135

Polymeric Nanomedicines Based on Poly(lactide) and Poly(lactide-co-glycolide).

Rong Tong1, Nathan P Gabrielson, Timothy M Fan, Jianjun Cheng.   

Abstract

Small molecule chemotherapeutics often have undesired physiochemical and pharmacological properties, such as low solubility, severe side effect and narrow therapeutic index. To address these challenges, polymeric nanomedicine drug delivery technology has been routinely employed, in particular with the use of biodegradable and biocompatible polyesters, such as poly(lactide) (PLA) and poly(lactide-co-glycolide) (PLGA). Here we review the development and use of PLA and PLGA for the delivery of chemotherapeutic agents in the forms of polymer-drug conjugates and nanoconjugates.

Entities:  

Keywords:  Cancer; PLA; PLGA; aptamer; cancer targeting; chemotherapeutics; drug delivery; nanoconjugates; nanomedicine; poly(lactide); poly(lactide-co-glycolide); polymer-drug conjugates

Year:  2012        PMID： 23914135      PMCID： PMC3728009          DOI： 10.1016/j.cossms.2013.01.001

Source DB:  PubMed          Journal:  Curr Opin Solid State Mater Sci        ISSN： 1359-0286            Impact factor:   11.354


  116 in total

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8.  A multifunctional biodegradable brush polymer-drug conjugate for paclitaxel/gemcitabine co-delivery and tumor imaging.

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  10 in total

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