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Literature DB >> 23913939

p63, Sharp1, and HIFs: master regulators of metastasis in triple-negative breast cancer.

Stefano Piccolo¹, Elena Enzo, Marco Montagner.

Abstract

Metastasis is the most significant cause of cancer-associated morbidity and mortality but remains poorly understood. Recent work revealed that metastasis of aggressive triple-negative breast cancers is suppressed by Sharp1, a factor that promotes degradation of hypoxia-inducible factors (HIF) and blunts HIF-induced malignant cell behavior.

Entities: Disease Gene

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Year: 2013 PMID： 23913939 DOI： 10.1158/0008-5472.CAN-13-0962

Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701

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Cited

13 in total

Review 1. Squamous Cell Cancers: A Unified Perspective on Biology and Genetics.

Authors: G Paolo Dotto; Anil K Rustgi
Journal: Cancer Cell Date: 2016-05-09 Impact factor: 31.743

2. FOXQ1 is overexpressed in laryngeal carcinoma and affects cell growth, cell cycle progression and cell invasion.

Authors: Jie Zhang; Wei Li; Song Dai; Xuhui Tai; Jianping Jia; Xing Guo
Journal: Oncol Lett Date: 2015-07-23 Impact factor: 2.967

3. Identification of Genes Regulating Breast Cancer Dormancy in 3D Bone Endosteal Niche Cultures.

Authors: Julie McGrath; Louis Panzica; Ryan Ransom; Henry G Withers; Irwin H Gelman
Journal: Mol Cancer Res Date: 2019-01-16 Impact factor: 5.852

4. Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments.

Authors: Georg Fluegen; Alvaro Avivar-Valderas; Yarong Wang; Michael R Padgen; James K Williams; Ana Rita Nobre; Veronica Calvo; Julie F Cheung; Jose Javier Bravo-Cordero; David Entenberg; James Castracane; Vladislav Verkhusha; Patricia J Keely; John Condeelis; Julio A Aguirre-Ghiso
Journal: Nat Cell Biol Date: 2017-01-23 Impact factor: 28.824

5. Demethylzeylasteral (T-96) inhibits triple-negative breast cancer invasion by blocking the canonical and non-canonical TGF-β signaling pathways.

Authors: Liu Li; Yi Ji; Junting Fan; Furong Li; Yan Li; Mianhua Wu; Haibo Cheng; Changliang Xu
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2019-02-06 Impact factor: 3.000

p63, Sharp1, and HIFs: master regulators of metastasis in triple-negative breast cancer.

Review 1. Squamous Cell Cancers: A Unified Perspective on Biology and Genetics.

2. FOXQ1 is overexpressed in laryngeal carcinoma and affects cell growth, cell cycle progression and cell invasion.

3. Identification of Genes Regulating Breast Cancer Dormancy in 3D Bone Endosteal Niche Cultures.

4. Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments.

5. Demethylzeylasteral (T-96) inhibits triple-negative breast cancer invasion by blocking the canonical and non-canonical TGF-β signaling pathways.

6. Hypoxia-induced autophagy contributes to radioresistance via c-Jun-mediated Beclin1 expression in lung cancer cells.

7. Trp63 is regulated by STAT5 in mammary tissue and subject to differentiation in cancer.

Review 8. The microRNA feedback regulation of p63 in cancer progression.

9. The downregulation of ΔNp63 in p53-deficient mouse epidermal tumors favors metastatic behavior.

10. p63 supports aerobic respiration through hexokinase II.