BACKGROUND: We aimed at establishing if the substitution of vascular age (VA) for chronological age (CA) causes a change in the Framingham Risk Score (FRS) categories. Sex differences in predictors of increased VA among cardiovascular (CV) risk factors and arterial stiffness (AS) parameters were identifi ed. METHODS: In 187 asymptomatic subjects with CV risk factors, classifi ed into 3 FRS categories the VA was derived from the nomograms of the carotid intima-media thickness. Two groups: 1 - subjects whose VA has exceeded CA for at least 5 years and 2 - others were established. Carotid AS parameters were obtained from echo-tracking. RESULTS: Substitution of VA for CA changed the FRS category into the higher one in 11.8% of subjects. Diabetes mellitus (DM) was the predictor of increased VA in both sexes, while metabolic syndrome (MS) only in women. The cut-off values of AS parameters that allow for prediction of increased VA were determined from the ROC-curve analysis - in men: b > 7.3, Ep > 103 kPa, AC < 0.61 mm2/kPa after adjustment for DM, BMI > 29.1 kg/m2, WHR > 0.85 and CA > 51 years; in women: b > 9.6, Ep > 126 kPa, AC < 0.75 mm2/kPa, PWV-b > 7.4 m/s after adjustment for DM, BMI > 25.8 kg/m2, WHR > 0.80 and CA > 60 years. CONCLUSIONS: The substitution of VA for CA may increase the FRS category. Sex differences in predictors of increased VA were identifi ed. AS parameters proved to be predictors of increased VA besides the classic risk factors.
BACKGROUND: We aimed at establishing if the substitution of vascular age (VA) for chronological age (CA) causes a change in the Framingham Risk Score (FRS) categories. Sex differences in predictors of increased VA among cardiovascular (CV) risk factors and arterial stiffness (AS) parameters were identifi ed. METHODS: In 187 asymptomatic subjects with CV risk factors, classifi ed into 3 FRS categories the VA was derived from the nomograms of the carotid intima-media thickness. Two groups: 1 - subjects whose VA has exceeded CA for at least 5 years and 2 - others were established. Carotid AS parameters were obtained from echo-tracking. RESULTS: Substitution of VA for CA changed the FRS category into the higher one in 11.8% of subjects. Diabetes mellitus (DM) was the predictor of increased VA in both sexes, while metabolic syndrome (MS) only in women. The cut-off values of AS parameters that allow for prediction of increased VA were determined from the ROC-curve analysis - in men: b > 7.3, Ep > 103 kPa, AC < 0.61 mm2/kPa after adjustment for DM, BMI > 29.1 kg/m2, WHR > 0.85 and CA > 51 years; in women: b > 9.6, Ep > 126 kPa, AC < 0.75 mm2/kPa, PWV-b > 7.4 m/s after adjustment for DM, BMI > 25.8 kg/m2, WHR > 0.80 and CA > 60 years. CONCLUSIONS: The substitution of VA for CA may increase the FRS category. Sex differences in predictors of increased VA were identifi ed. AS parameters proved to be predictors of increased VA besides the classic risk factors.
Authors: Stefan Betge; Daniel Kretzschmar; Hans-Reiner Figulla; Michael Lichtenauer; Christian Jung Journal: Heart Vessels Date: 2016-07-11 Impact factor: 2.037
Authors: Małgorzata Dec-Gilowska; Marcin Trojnar; Bogusław Makaruk; Barbara Mosiewicz-Madejska; Grzegorz Dzida; Jerzy Mosiewicz Journal: J Int Med Res Date: 2020-09 Impact factor: 1.671
Authors: Malgorzata Dec-Gilowska; Marcin Trojnar; Boguslaw Makaruk; Marcin Czop; Sylwia Przybylska-Kuc; Barbara Mosiewicz-Madejska; Grzegorz Dzida; Jerzy Mosiewicz Journal: Medicina (Kaunas) Date: 2019-09-16 Impact factor: 2.430