Literature DB >> 23912660

A complex neurological presentation of syphilis.

Max Kamath1, Maleeha Rizvi, Jenny O'Nions, Gary Brook.   

Abstract

Syphilis is a contagious sexually transmitted infection notable for its complex array of systemic presentations. It is caused by the spirochaete Treponema pallidum and although once considered to be a largely historical condition in the UK, the recent rise in incidence makes syphilis increasingly relevant when considering unusual presentations in at-risk patients. The disease has three stages: primary, secondary and tertiary. The tertiary stage is associated with a plethora of neurological features ranging from psychosis to seizure caused by direct invasion of the spirochaete into the central nervous system. Here we describe the case of a 45-year-old man presenting with tonic clonic seizures on a background of balance and visual problems. Following normal examination and routine investigations further serology confirmed a diagnosis of neurosyphilis. The patient was started on appropriate treatment and made an excellent clinical recovery.

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Mesh:

Year:  2013        PMID: 23912660      PMCID: PMC3762418          DOI: 10.1136/bcr-2013-200309

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  15 in total

Review 1.  Syphilis: review with emphasis on clinical, epidemiologic, and some biologic features.

Authors:  A E Singh; B Romanowski
Journal:  Clin Microbiol Rev       Date:  1999-04       Impact factor: 26.132

2.  Treatment of neurosyphilis with ceftriaxone.

Authors:  S Shann; J Wilson
Journal:  Sex Transm Infect       Date:  2003-10       Impact factor: 3.519

3.  The Oslo study of untreated syphilis; an epidemiologic investigation of the natural course of the syphilitic infection based upon a re-study of the Boeck-Bruusgaard material.

Authors:  T Gjestland
Journal:  Acta Derm Venereol Suppl (Stockh)       Date:  1955

Review 4.  The performance of cerebrospinal fluid treponemal-specific antibody tests in neurosyphilis: a systematic review.

Authors:  Alexander S Harding; Khalil G Ghanem
Journal:  Sex Transm Dis       Date:  2012-04       Impact factor: 2.830

5.  Low rate of syphilis screening among high-risk emergency department patients tested for gonorrhea and chlamydia infections.

Authors:  Douglas A E White; Harrison J Alter; Nathan A Irvin; Melissa C Clark; Bradley W Frazee
Journal:  Sex Transm Dis       Date:  2012-04       Impact factor: 2.830

6.  Seizure disorders associated with neurosyphilis.

Authors:  H Hooshmand
Journal:  Dis Nerv Syst       Date:  1976-03

7.  Status epilepticus revealing syphilitic meningoencephalitis.

Authors:  Imane Hajjaj; Najib Kissani
Journal:  Acta Neurol Belg       Date:  2010-09       Impact factor: 2.396

8.  Management of adult syphilis.

Authors:  Khalil G Ghanem; Kimberly A Workowski
Journal:  Clin Infect Dis       Date:  2011-12       Impact factor: 9.079

9.  Neurosyphilis masquerading as hemiparesis and Jacksonian epilepsy in an HIV positive patient: a case report.

Authors:  P S Kyebambe
Journal:  Afr Health Sci       Date:  2010-06       Impact factor: 0.927

10.  Neurosyphilis in the modern era.

Authors:  M Timmermans; J Carr
Journal:  J Neurol Neurosurg Psychiatry       Date:  2004-12       Impact factor: 10.154

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  1 in total

1.  Acute cranial neuropathies heralding neurosyphilis in human immunodeficiency virus-infected patient.

Authors:  Saeed Alqahtani
Journal:  Am J Case Rep       Date:  2014-09-25
  1 in total

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