OBJECTIVE: Evaluating the effect of ivermectin on soil-transmitted helminthes (STH) infection frequency in a Colombian population included in the Onchocerciasis Elimination Program for the Americas (OEPA). METHODS: This was an impact evaluation study which adopted a longitudinal approach using the population of Naicioná (1996) as baseline for comparison to people from the same population as controls (2008). The cross-sectional approach involved comparing the reference population of Naicioná (2008) to the population of Dos Quebradas (2008) used as controls. Fecal samples were processed by a modified Ritchie-Frick method. RESULTS: Ascaris lumbricoides was the most frequently found parasite in Naicioná (60/121; 49.6 %: 37.8-63.895%CI) and in Dos Quebradas (36/76; 47.4 %: 33.2-65.6 95 % CI). Ivermectin's main effect on the population aged over 5 years was a decreased risk of Trichiuris trichiura infection in both longitudinal assessment (86 % reduction: 74-93 95 % CI) and cross-sectional assessment (63 %:24-82 95 % CI). A 93 % reduction (45-99 95 % CI) in Strongyloides stercoralis frequency was found in longitudinal assessment, compared to 85 % in cross-sectional assessment (-031-99 95 % CI). CONCLUSIONS: Ivermectin use in the OEPA is not sufficient for STH morbidity control. Integrated programs including education and basic sanitation are required.
OBJECTIVE: Evaluating the effect of ivermectin on soil-transmitted helminthes (STH) infection frequency in a Colombian population included in the Onchocerciasis Elimination Program for the Americas (OEPA). METHODS: This was an impact evaluation study which adopted a longitudinal approach using the population of Naicioná (1996) as baseline for comparison to people from the same population as controls (2008). The cross-sectional approach involved comparing the reference population of Naicioná (2008) to the population of Dos Quebradas (2008) used as controls. Fecal samples were processed by a modified Ritchie-Frick method. RESULTS:Ascaris lumbricoides was the most frequently found parasite in Naicioná (60/121; 49.6 %: 37.8-63.895%CI) and in Dos Quebradas (36/76; 47.4 %: 33.2-65.6 95 % CI). Ivermectin's main effect on the population aged over 5 years was a decreased risk of Trichiuris trichiura infection in both longitudinal assessment (86 % reduction: 74-93 95 % CI) and cross-sectional assessment (63 %:24-82 95 % CI). A 93 % reduction (45-99 95 % CI) in Strongyloides stercoralis frequency was found in longitudinal assessment, compared to 85 % in cross-sectional assessment (-031-99 95 % CI). CONCLUSIONS: Ivermectin use in the OEPA is not sufficient for STH morbidity control. Integrated programs including education and basic sanitation are required.
Authors: Kevin C Kobylinski; Karín S Escobedo-Vargas; Victor M López-Sifuentes; Salomón Durand; Edward S Smith; G Christian Baldeviano; Robert V Gerbasi; Sara-Blythe Ballard; Craig A Stoops; Gissella M Vásquez Journal: Malar J Date: 2017-11-21 Impact factor: 2.979
Authors: Podjanee Jittamala; Wuelton Monteiro; Menno R Smit; Belen Pedrique; Sabine Specht; Carlos J Chaccour; Céline Dard; Pascal Del Giudice; Virak Khieu; Annabel Maruani; Virgilio E Failoc-Rojas; Marimar Sáez-de-Ocariz; Antoni Soriano-Arandes; Jaime Piquero-Casals; Anne Faisant; Marie-Pierre Brenier-Pinchart; David Wimmersberger; Jean T Coulibaly; Jennifer Keiser; Franck Boralevi; Oliver Sokana; Michael Marks; Daniel Engelman; Lucia Romani; Andrew C Steer; Lorenz von Seidlein; Nicholas J White; Eli Harriss; Kasia Stepniewska; Georgina S Humphreys; Kalynn Kennon; Philippe J Guerin; Kevin C Kobylinski Journal: PLoS Negl Trop Dis Date: 2021-03-17