From skin to blood: a new member joins the iClub.

Transcription-factor-driven direct reprogramming allows lineage conversion of somatic cells that bypasses an intermediate pluripotent state. In this issue of Cell Stem Cell, Pereira et al. (2013) report the induction of cells with hemogenic potential from murine fibroblasts, an important step toward generating patient-specific hematopoietic (stem) cells for clinical application.