Lin Zhao1, Lutian Yao, Lin Yuan, Liping Xia, Hui Shen, Jing Lu. 1. Department of Rheumatology, 1st Affiliated Hospital of China Medical University, Shenyang 110001, PR China; Department of Rheumatology, 2nd Affiliated Hospital of Dalian Medical University, Dalian 116021, PR China.
Abstract
OBJECTIVE: To determine whether interleukin (IL)-33 and soluble ST2 (sST2) are associated with primary Sjogren's Syndrome (pSS). METHODS: Serum levels of IL-33 and sST2 in 110 pSS patients and 78 healthy controls were measured by enzyme-linked immunosorbent assay (ELISA). Immunoglobulins, rheumatoid factors (RF), antinuclear antibody (ANA), anti-SSA/RO-52 antibody, anti-SSB antibody and erythrocyte sedimentation rate (ESR) were measured by standard laboratory techniques. Interstitial lung disease (ILD) was identified on high-resolution computed tomography (HRCT). Disease activity in pSS was scored with the European League Against Rheumatism Sjogren's Syndrome Disease Activity Index (ESSDAI). RESULTS: Serum levels of IL-33 and sST2 were significantly elevated in pSS patients, especially in patients with ILD. There was significant positive correlation between IL-33 and RF, anti-SSB antibody. CONCLUSION: IL-33/sST2 may be involved in the pathogenesis of pSS and partly contribute to the ILD in pSS patients.
OBJECTIVE: To determine whether interleukin (IL)-33 and soluble ST2 (sST2) are associated with primary Sjogren's Syndrome (pSS). METHODS: Serum levels of IL-33 and sST2 in 110 pSSpatients and 78 healthy controls were measured by enzyme-linked immunosorbent assay (ELISA). Immunoglobulins, rheumatoid factors (RF), antinuclear antibody (ANA), anti-SSA/RO-52 antibody, anti-SSB antibody and erythrocyte sedimentation rate (ESR) were measured by standard laboratory techniques. Interstitial lung disease (ILD) was identified on high-resolution computed tomography (HRCT). Disease activity in pSS was scored with the European League Against Rheumatism Sjogren's Syndrome Disease Activity Index (ESSDAI). RESULTS: Serum levels of IL-33 and sST2 were significantly elevated in pSSpatients, especially in patients with ILD. There was significant positive correlation between IL-33 and RF, anti-SSB antibody. CONCLUSION:IL-33/sST2 may be involved in the pathogenesis of pSS and partly contribute to the ILD in pSSpatients.
Authors: Xin Long; Michelle Daya; Jianping Zhao; Nicholas Rafaels; Huifang Liang; Joseph Potee; Monica Campbell; Bixiang Zhang; Maria Ilma Araujo; Ricardo R Oliveira; Rasika A Mathias; Li Gao; Ingo Ruczinski; Steve N Georas; Donata Vercelli; Terri H Beaty; Kathleen C Barnes; Xiaoping Chen; Qian Chen Journal: J Allergy Clin Immunol Date: 2017-02-09 Impact factor: 10.793