N Duman1, S Ersoy Evans, N Atakan. 1. Department of Dermatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Abstract
BACKGROUND AND OBJECTIVE: Rosacea is an inflammatory skin disease with a chronic course. This study aimed to investigate the risk of cardiovascular disease (CVD) in rosacea patients. MATERIALS AND METHODS: The study included 60 rosacea patients and 50 age- and gender-matched controls. Demographic data, medical history, presence of cardiovascular risk factors were recorded. Waist circumference, height, and weight were measured, and the body mass index was calculated for each participant. Laboratory investigations, including fasting blood glucose, C-reactive protein (CRP), very low-density lipoprotein, low-density lipoprotein (LDL), high-density lipoprotein, total cholesterol, triglyceride, lipoprotein(a) were performed. RESULTS: In all, 66% of the rosacea patients were female (mean age: 44.65 ± 12.9 years) and 66% of the controls were female (mean age: 42.3 ± 12.3 years). Median disease duration in the rosacea group was 36 months. High total cholesterol (>200 mg/dL), LDL (>130 mg/dL) and CRP (>0.8 mg/L) levels, a family history of premature CVD, and a history of smoking and alcohol consumption were significantly more common in the rosacea patients compared to controls. CONCLUSION: Rosacea patients may have a high risk of CVD. As such, we recommend close follow-up of rosacea patients because of the increased risk of CVD. The mechanism underlying this increased risk is unknown, and additional randomized and controlled studies are required for clarification.
BACKGROUND AND OBJECTIVE:Rosacea is an inflammatory skin disease with a chronic course. This study aimed to investigate the risk of cardiovascular disease (CVD) in rosaceapatients. MATERIALS AND METHODS: The study included 60 rosaceapatients and 50 age- and gender-matched controls. Demographic data, medical history, presence of cardiovascular risk factors were recorded. Waist circumference, height, and weight were measured, and the body mass index was calculated for each participant. Laboratory investigations, including fasting blood glucose, C-reactive protein (CRP), very low-density lipoprotein, low-density lipoprotein (LDL), high-density lipoprotein, total cholesterol, triglyceride, lipoprotein(a) were performed. RESULTS: In all, 66% of the rosaceapatients were female (mean age: 44.65 ± 12.9 years) and 66% of the controls were female (mean age: 42.3 ± 12.3 years). Median disease duration in the rosacea group was 36 months. High total cholesterol (>200 mg/dL), LDL (>130 mg/dL) and CRP (>0.8 mg/L) levels, a family history of premature CVD, and a history of smoking and alcohol consumption were significantly more common in the rosaceapatients compared to controls. CONCLUSION:Rosaceapatients may have a high risk of CVD. As such, we recommend close follow-up of rosaceapatients because of the increased risk of CVD. The mechanism underlying this increased risk is unknown, and additional randomized and controlled studies are required for clarification.
Authors: Bo Young Chung; Hye One Kim; Chun Wook Park; Na Gyeong Yang; Jae Yun Kim; Yun Su Eun; Euy Hyun Chung; Sung Yul Lee; Young Lip Park; Sang Hoon Lee; Nam Hun Heo; Min Jeong Shin; Jung Eun Kim Journal: Biomed Res Int Date: 2022-07-04 Impact factor: 3.246