Literature DB >> 23909856

Palladium-catalyzed direct intermolecular α-arylation of amides with aryl chlorides.

Bing Zheng1, Tiezheng Jia, Patrick J Walsh.   

Abstract

An efficient catalytic system for the direct intermolecular α-arylation of acetamide derivatives with aryl chlorides is presented. Chemoselectivities up to 10:1 in the mono- and diarylation of acetamides were achieved by careful selection of bases, solvents, and stoichiometry. Bis-arylated amides were prepared in up to 95% yield.

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Year:  2013        PMID： 23909856     DOI： 10.1021/ol4019002

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  20 in total

1.  A General and Practical Palladium-Catalyzed Direct α-Arylation of Amides with Aryl Halides.

Authors:  Bing Zheng; Tiezheng Jia; Patrick J Walsh
Journal:  Adv Synth Catal       Date:  2014-01-13       Impact factor: 5.837

2.  Palladium-Catalyzed α-Arylation of Methyl Sulfonamides with Aryl Chlorides.

Authors:  Bing Zheng; Minyan Li; Gui Gao; Yuying He; Patrick J Walsh
Journal:  Adv Synth Catal       Date:  2016-06-15       Impact factor: 5.837

3.  Tandem C(sp3)-H Arylation/Oxidation and Arylation/Allylic Substitution of Isoindolinones.

Authors:  Jacqueline Jiménez; Byeong-Seon Kim; Patrick J Walsh
Journal:  Adv Synth Catal       Date:  2016-08-02       Impact factor: 5.837

4.  Reversed-Polarity Synthesis of Diaryl Ketones through Palladium-Catalyzed Direct Arylation of 2-Aryl-1,3-dithianes.

Authors:  Baris Yucel; Patrick J Walsh
Journal:  Adv Synth Catal       Date:  2014-11-24       Impact factor: 5.837

5.  Palladium-Catalyzed Benzylic C-H Arylation of Azaarylmethylamines.

Authors:  Byeong-Seon Kim; Jacqueline Jiménez; Feng Gao; Patrick J Walsh
Journal:  Org Lett       Date:  2015-11-17       Impact factor: 6.005

6.  Chemo- and regioselective C(sp³)-H arylation of unactivated allylarenes by deprotonative cross-coupling.

Authors:  Nusrah Hussain; Gustavo Frensch; Jiadi Zhang; Patrick J Walsh
Journal:  Angew Chem Int Ed Engl       Date:  2014-02-26       Impact factor: 15.336

7.  Palladium-catalyzed α-arylation of benzylic phosphine oxides.

Authors:  Sonia Montel; Tiezheng Jia; Patrick J Walsh
Journal:  Org Lett       Date:  2013-12-02       Impact factor: 6.005

8.  Palladium-Catalyzed Benzylic Arylation of Pyridylmethyl Silyl Ethers: One-Pot Synthesis of Aryl(pyridyl)methanols.

Authors:  Alexandra R Rivero; Byeong-Seon Kim; Patrick J Walsh
Journal:  Org Lett       Date:  2016-03-23       Impact factor: 6.005

9.  Room-temperature palladium-catalyzed direct 2-arylation of benzoxazoles with aryl and heteroaryl bromides.

Authors:  Feng Gao; Byeong-Seon Kim; Patrick J Walsh
Journal:  Chem Commun (Camb)       Date:  2014-07-31       Impact factor: 6.222

10.  Synthesis of triarylmethanols via tandem arylation/oxidation of diarylmethanes.

Authors:  Jianyou Mao; Kelly Eberle; Jiadi Zhang; Carles Rodriguez; Zhenfeng Xi; Miquel A Pericàs; Patrick J Walsh
Journal:  Tetrahedron Lett       Date:  2015-06-03       Impact factor: 2.415
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