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Literature DB >> 23909613

Direct transformation of amides into α-amino phosphonates via a reductive phosphination process.

Yuzhen Gao¹, Zhongbin Huang, Rongqiang Zhuang, Jian Xu, Pengbo Zhang, Guo Tang, Yufen Zhao.

Abstract

The first general method for the reductive phosphination of amides in one pot has been developed. The reactions described provide a novel access to α-amino phosphonates in good to excellent yields, cover a broad scope of substrates such as secondary and tertiary amides, and do not require a low temperature.

Entities: Chemical

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Year: 2013 PMID： 23909613 DOI： 10.1021/ol4019419

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

4 in total

1. Relationship between Structure and Antibacterial Activity of α-Aminophosphonate Derivatives Obtained via Lipase-Catalyzed Kabachnik-Fields Reaction.

Authors: Dominik Koszelewski; Paweł Kowalczyk; Paweł Śmigielski; Jan Samsonowicz-Górski; Karol Kramkowski; Aleksandra Wypych; Mateusz Szymczak; Ryszard Ostaszewski
Journal: Materials (Basel) Date: 2022-05-27 Impact factor: 3.748

Direct transformation of amides into α-amino phosphonates via a reductive phosphination process.

1. Relationship between Structure and Antibacterial Activity of α-Aminophosphonate Derivatives Obtained via Lipase-Catalyzed Kabachnik-Fields Reaction.

2. Metal- and solvent-free synthesis of amides using substitute formamides as an amino source under mild conditions.

3. The synthesis of HMF-based α-amino phosphonates via one-pot Kabachnik-Fields reaction.

4. Electrophile-Dependent Reactivity of Lithiated N-Benzylpyrene-1-Carboxamide.