Literature DB >> 23908481

Estimation of the association between antibody titers and protection against confirmed influenza virus infection in children.

Sophia Ng1, Vicky J Fang, Dennis K M Ip, Kwok-Hung Chan, Gabriel M Leung, J S Malik Peiris, Benjamin J Cowling.   

Abstract

Antibody titers measured by hemagglutination inhibition (HAI) correlate with protection against influenza virus infection and are used to specify criteria for vaccine licensure. In a randomized, controlled trial of seasonal influenza vaccination in 773 children aged 6-17 years, we estimated that HAI titers of 1:40 against A(H1N1)pdm09 and B(Victoria lineage) were associated with 48% (95% confidence interval [CI], 30%-62%) and 55% (95% CI, 32%-70%) protection against PCR-confirmed infection with each strain. Our analysis accounted for waning in antibody titers over time, and could be particularly useful in settings where influenza activity is delayed or prolonged relative to measurement of antibody titers.

Entities:  

Keywords:  antibody; children; immunity; influenza; vaccine

Mesh：

Substances：

Year:  2013        PMID： 23908481      PMCID： PMC3778972          DOI： 10.1093/infdis/jit372

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  14 in total

1.  Efficacy studies of influenza vaccines: effect of end points used and characteristics of vaccine failures.

Authors:  Joshua G Petrie; Suzanne E Ohmit; Emileigh Johnson; Rachel T Cross; Arnold S Monto
Journal:  J Infect Dis       Date:  2011-03-04       Impact factor: 5.226

2.  The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B viruses.

Authors:  D Hobson; R L Curry; A S Beare; A Ward-Gardner
Journal:  J Hyg (Lond)       Date:  1972-12

Review 3.  Correlates of protection to influenza virus, where do we go from here?

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Authors:  R B Belshe; W C Gruber; P M Mendelman; H B Mehta; K Mahmood; K Reisinger; J Treanor; K Zangwill; F G Hayden; D I Bernstein; K Kotloff; J King; P A Piedra; S L Block; L Yan; M Wolff
Journal:  J Infect Dis       Date:  2000-03       Impact factor: 5.226

5.  Influenza hemagglutination-inhibition antibody titer as a correlate of vaccine-induced protection.

Authors:  Suzanne E Ohmit; Joshua G Petrie; Rachel T Cross; Emileigh Johnson; Arnold S Monto
Journal:  J Infect Dis       Date:  2011-10-12       Impact factor: 5.226

6.  Protective efficacy of seasonal influenza vaccination against seasonal and pandemic influenza virus infection during 2009 in Hong Kong.

Authors:  Benjamin J Cowling; Sophia Ng; Edward S K Ma; Calvin K Y Cheng; Winnie Wai; Vicky J Fang; Kwok-Hung Chan; Dennis K M Ip; Susan S Chiu; J S Malik Peiris; Gabriel M Leung
Journal:  Clin Infect Dis       Date:  2010-11-10       Impact factor: 9.079

7.  Relationship between haemagglutination-inhibiting antibody titres and clinical protection against influenza: development and application of a bayesian random-effects model.

Authors:  Laurent Coudeville; Fabrice Bailleux; Benjamin Riche; Françoise Megas; Philippe Andre; René Ecochard
Journal:  BMC Med Res Methodol       Date:  2010-03-08       Impact factor: 4.615

8.  Influenzavirus infections in Seattle families, 1975-1979. II. Pattern of infection in invaded households and relation of age and prior antibody to occurrence of infection and related illness.

Authors:  J P Fox; M K Cooney; C E Hall; H M Foy
Journal:  Am J Epidemiol       Date:  1982-08       Impact factor: 4.897

9.  Time to peak serum antibody response to influenza vaccine.

Authors:  S Rastogi; P A Gross; J Bonelli; S Dran; R A Levandowski; C Russo; M E Weksler; D Kaye; M Levison; E Abrutyn
Journal:  Clin Diagn Lab Immunol       Date:  1995-01

10.  Persistence of influenza serum antibodies in humans following immunization with a bivalent A/Victoria and A/New Jersey vaccine.

Authors:  D W Boucher; G Contreras; J Furesz
Journal:  Can Med Assoc J       Date:  1979-04-07       Impact factor: 8.262
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  36 in total

1.  Profiles of influenza A/H1N1 vaccine response using hemagglutination-inhibition titers.

Authors:  Robert M Jacobson; Diane E Grill; Ann L Oberg; Pritish K Tosh; Inna G Ovsyannikova; Gregory A Poland
Journal:  Hum Vaccin Immunother       Date:  2015       Impact factor: 3.452

2.  Effectiveness of influenza vaccination on influenza-associated hospitalisations over time among children in Hong Kong: a test-negative case-control study.

Authors:  Shuo Feng; Susan S Chiu; Eunice L Y Chan; Mike Y W Kwan; Joshua S C Wong; Chi-Wai Leung; Yiu Chung Lau; Sheena G Sullivan; J S Malik Peiris; Benjamin J Cowling
Journal:  Lancet Respir Med       Date:  2018-11-12       Impact factor: 30.700

3.  Influenza Hemagglutination-inhibition Antibody Titer as a Mediator of Vaccine-induced Protection for Influenza B.

Authors:  Benjamin J Cowling; Wey Wen Lim; Ranawaka A P M Perera; Vicky J Fang; Gabriel M Leung; J S Malik Peiris; Eric J Tchetgen Tchetgen
Journal:  Clin Infect Dis       Date:  2019-05-02       Impact factor: 9.079

4.  The Effectiveness of Trivalent Inactivated Influenza Vaccine in Children with Acute Leukemia.

Authors:  April Sykes; Elsie Gerhardt; Li Tang; Elisabeth E Adderson
Journal:  J Pediatr       Date:  2017-12       Impact factor: 4.406

5.  A Synthetic Micro-Consensus DNA Vaccine Generates Comprehensive Influenza A H3N2 Immunity and Protects Mice Against Lethal Challenge by Multiple H3N2 Viruses.

Authors:  Sarah T C Elliott; Amelia A Keaton; Jacqueline D Chu; Charles C Reed; Bradley Garman; Ami Patel; Jian Yan; Kate E Broderick; David B Weiner
Journal:  Hum Gene Ther       Date:  2018-09       Impact factor: 5.695

6.  Relationship of preexisting influenza hemagglutination inhibition, complement-dependent lytic, and antibody-dependent cellular cytotoxicity antibodies to the development of clinical illness in a prospective study of A(H1N1)pdm09 Influenza in children.

Authors:  Mary Dawn T Co; Masanori Terajima; Stephen J Thomas; Richard G Jarman; Kamonthip Rungrojcharoenkit; Stefan Fernandez; In-Kyu Yoon; Darunee Buddhari; John Cruz; Francis A Ennis
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7.  Immunogenicity of seasonal inactivated influenza and inactivated polio vaccines among children in Senegal: Results from a cluster-randomized trial.

Authors:  Mbayame Niang; Meagan E Deming; Deborah Goudiaby; Ousmane M Diop; Ndongo Dia; Aldiouma Diallo; Justin R Ortiz; Doudou Diop; Kristen D C Lewis; Kathryn E Lafond; Marc-Alain Widdowson; John C Victor; Kathleen M Neuzil
Journal:  Vaccine       Date:  2020-10-02       Impact factor: 3.641

8.  Association between antibody titers and protection against influenza virus infection within households.

Authors:  Tim K Tsang; Simon Cauchemez; Ranawaka A P M Perera; Guy Freeman; Vicky J Fang; Dennis K M Ip; Gabriel M Leung; Joseph Sriyal Malik Peiris; Benjamin J Cowling
Journal:  J Infect Dis       Date:  2014-03-26       Impact factor: 5.226

9.  Interpreting Seroepidemiologic Studies of Influenza in a Context of Nonbracketing Sera.

Authors:  Tim K Tsang; Vicky J Fang; Ranawaka A P M Perera; Dennis K M Ip; Gabriel M Leung; J S Malik Peiris; Simon Cauchemez; Benjamin J Cowling
Journal:  Epidemiology       Date:  2016-01       Impact factor: 4.822

10.  Seasonal Influenza Vaccination of Children Induces Humoral and Cell-Mediated Immunity Beyond the Current Season: Cross-reactivity With Past and Future Strains.

Authors:  Adrian J Reber; Jin Hyang Kim; Laura A Coleman; Sarah M Spencer; Jessie R Chung; Jufu Chen; Paul Gargiullo; Maria E Sundaram; Edward A Belongia; David K Shay; Jacqueline M Katz; Suryaprakash Sambhara
Journal:  J Infect Dis       Date:  2016-08-28       Impact factor: 5.226
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