BACKGROUND: The purpose of our study was to determine whether preoperative diabetes mellitus (DM) can predict the prognosis of localized clear-cell renal cell carcinoma (RCC). METHODS: At five institutes, 2,597 patients with pT1 and pT2 clear-cell RCC were enrolled. Univariate and multivariable analyses were performed to determine factors that associated with recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS). To identify the effect of DM on survival after recurrence, a subgroup of 127 patients who had recurrences was analyzed. RESULTS: In total, 357 patients had DM. Compared with patients without DM, these patients were older, more likely to be male, and had a higher body mass index, lower GFR, and higher incidence of hypertension. Kaplan-Meier curves showed that patients with DM had a significantly worse rate of RFS, CSS, and OS than patients without DM (log-rank test, all P < 0.05). Multivariate analysis revealed that DM was an independent prognostic factor in terms of RFS, CSS, and OS. In the subgroup analysis of 127 patients with recurrence, DM was associated with a lower survival rate after the initial recurrence. CONCLUSIONS: DM appeared to be an important determinant of prognosis in clear-cell localized RCC, especially in patients experiencing recurrence.
BACKGROUND: The purpose of our study was to determine whether preoperative diabetes mellitus (DM) can predict the prognosis of localized clear-cell renal cell carcinoma (RCC). METHODS: At five institutes, 2,597 patients with pT1 and pT2 clear-cell RCC were enrolled. Univariate and multivariable analyses were performed to determine factors that associated with recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS). To identify the effect of DM on survival after recurrence, a subgroup of 127 patients who had recurrences was analyzed. RESULTS: In total, 357 patients had DM. Compared with patients without DM, these patients were older, more likely to be male, and had a higher body mass index, lower GFR, and higher incidence of hypertension. Kaplan-Meier curves showed that patients with DM had a significantly worse rate of RFS, CSS, and OS than patients without DM (log-rank test, all P < 0.05). Multivariate analysis revealed that DM was an independent prognostic factor in terms of RFS, CSS, and OS. In the subgroup analysis of 127 patients with recurrence, DM was associated with a lower survival rate after the initial recurrence. CONCLUSIONS:DM appeared to be an important determinant of prognosis in clear-cell localized RCC, especially in patients experiencing recurrence.
Authors: Madhur Nayan; Antonio Finelli; Michael A S Jewett; David N Juurlink; Peter C Austin; Girish S Kulkarni; Robert J Hamilton Journal: Endocrine Date: 2016-11-04 Impact factor: 3.633
Authors: Thomas Höfner; Martin Zeier; Gencay Hatiboglu; Christian Eisen; Gita Schönberg; Boris Hadaschik; Dogu Teber; Stefan Duensing; Andreas Trumpp; Markus Hohenfellner; Sascha Pahernik Journal: World J Urol Date: 2013-12-27 Impact factor: 4.226
Authors: Antonio Vavallo; Simona Simone; Giuseppe Lucarelli; Monica Rutigliano; Vanessa Galleggiante; Giuseppe Grandaliano; Loreto Gesualdo; Marcello Campagna; Marica Cariello; Elena Ranieri; Giovanni Pertosa; Gaetano Lastilla; Francesco Paolo Selvaggi; Pasquale Ditonno; Michele Battaglia Journal: Medicine (Baltimore) Date: 2014-12 Impact factor: 1.889