Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 p73 keeps metabolic control in the family.

Literature DB >> 23907193

p73 keeps metabolic control in the family.

Abstract

The transcription factor p73, a close relative of p53, has complex yet poorly understood roles in tumorigenesis. TAp73, a p73 variant, has now been shown to promote cancer cell proliferation by regulating glucose metabolism to control cellular biosynthetic pathways and antioxidant capacity.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2013 PMID： 23907193 DOI： 10.1038/ncb2810

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

15 in total

1. TIGAR, a p53-inducible regulator of glycolysis and apoptosis.

Authors: Karim Bensaad; Atsushi Tsuruta; Mary A Selak; M Nieves Calvo Vidal; Katsunori Nakano; Ramon Bartrons; Eyal Gottlieb; Karen H Vousden
Journal: Cell Date: 2006-07-14 Impact factor: 41.582

Review 2. Cellular metabolic stress: considering how cells respond to nutrient excess.

Authors: Kathryn E Wellen; Craig B Thompson
Journal: Mol Cell Date: 2010-10-22 Impact factor: 17.970

3. The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.

Authors: Mariia O Yuneva; Teresa W M Fan; Thaddeus D Allen; Richard M Higashi; Dana V Ferraris; Takashi Tsukamoto; José M Matés; Francisco J Alonso; Chunmei Wang; Youngho Seo; Xin Chen; J Michael Bishop
Journal: Cell Metab Date: 2012-02-08 Impact factor: 27.287

Review 4. How cancer metabolism is tuned for proliferation and vulnerable to disruption.

Authors: Almut Schulze; Adrian L Harris
Journal: Nature Date: 2012-11-15 Impact factor: 49.962

5. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment.

Authors: Zachary T Schafer; Alexandra R Grassian; Loling Song; Zhenyang Jiang; Zachary Gerhart-Hines; Hanna Y Irie; Sizhen Gao; Pere Puigserver; Joan S Brugge
Journal: Nature Date: 2009-08-19 Impact factor: 49.962

6. TAp73 depletion accelerates aging through metabolic dysregulation.

Authors: Alessandro Rufini; Maria Victoria Niklison-Chirou; Satoshi Inoue; Richard Tomasini; Isaac S Harris; Arianna Marino; Massimo Federici; David Dinsdale; Richard A Knight; Gerry Melino; Tak Wah Mak
Journal: Genes Dev Date: 2012-09-15 Impact factor: 11.361

Review 7. p73: Friend or foe in tumorigenesis.

Authors: Gerry Melino; Vincenzo De Laurenzi; Karen H Vousden
Journal: Nat Rev Cancer Date: 2002-08 Impact factor: 60.716

8. TAp73 knockout shows genomic instability with infertility and tumor suppressor functions.

Authors: Richard Tomasini; Katsuya Tsuchihara; Margareta Wilhelm; Masashi Fujitani; Alessandro Rufini; Carol C Cheung; Fatima Khan; Annick Itie-Youten; Andrew Wakeham; Ming-Sound Tsao; Juan L Iovanna; Jeremy Squire; Igor Jurisica; David Kaplan; Gerry Melino; Andrea Jurisicova; Tak W Mak
Journal: Genes Dev Date: 2008-09-19 Impact factor: 11.361

9. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.

Authors: Dimitrios Anastasiou; Yimin Yu; William J Israelsen; Jian-Kang Jiang; Matthew B Boxer; Bum Soo Hong; Wolfram Tempel; Svetoslav Dimov; Min Shen; Abhishek Jha; Hua Yang; Katherine R Mattaini; Christian M Metallo; Brian P Fiske; Kevin D Courtney; Scott Malstrom; Tahsin M Khan; Charles Kung; Amanda P Skoumbourdis; Henrike Veith; Noel Southall; Martin J Walsh; Kyle R Brimacombe; William Leister; Sophia Y Lunt; Zachary R Johnson; Katharine E Yen; Kaiko Kunii; Shawn M Davidson; Heather R Christofk; Christopher P Austin; James Inglese; Marian H Harris; John M Asara; Gregory Stephanopoulos; Francesco G Salituro; Shengfang Jin; Lenny Dang; Douglas S Auld; Hee-Won Park; Lewis C Cantley; Craig J Thomas; Matthew G Vander Heiden
Journal: Nat Chem Biol Date: 2012-10 Impact factor: 15.040