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Literature DB >> 23907192

The multiple talents of kinesin-8.

Abstract

Multiple activities cooperate to determine the architecture of the mitotic spindle. Kip3 is a kinesin-8 motor protein in budding yeast that acts as a microtubule depolymerase. Now Kip3 is shown to also crosslink and slide antiparallel microtubules, providing additional insights into how kinesin-8 motors control spindle integrity.

Entities: Gene Species

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Year: 2013 PMID： 23907192 DOI： 10.1038/ncb2820

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

16 in total

1. The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks.

Authors: Lukas C Kapitein; Erwin J G Peterman; Benjamin H Kwok; Jeffrey H Kim; Tarun M Kapoor; Christoph F Schmidt
Journal: Nature Date: 2005-05-05 Impact factor: 49.962

2. Phosphorylation-dependent protein interactions at the spindle midzone mediate cell cycle regulation of spindle elongation.

Authors: Anton Khmelinskii; Johanna Roostalu; Helio Roque; Claude Antony; Elmar Schiebel
Journal: Dev Cell Date: 2009-08 Impact factor: 12.270

3. A tethering mechanism controls the processivity and kinetochore-microtubule plus-end enrichment of the kinesin-8 Kif18A.

Authors: Jason Stumpff; Yaqing Du; Chauca A English; Zoltan Maliga; Michael Wagenbach; Charles L Asbury; Linda Wordeman; Ryoma Ohi
Journal: Mol Cell Date: 2011-09-02 Impact factor: 17.970

The multiple talents of kinesin-8.

1. The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks.

2. Phosphorylation-dependent protein interactions at the spindle midzone mediate cell cycle regulation of spindle elongation.

3. A tethering mechanism controls the processivity and kinetochore-microtubule plus-end enrichment of the kinesin-8 Kif18A.

4. Mechanisms underlying the dual-mode regulation of microtubule dynamics by Kip3/kinesin-8.

5. Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner.

6. Kinesin-8 is a low-force motor protein with a weakly bound slip state.

7. Microtubule-sliding activity of a kinesin-8 promotes spindle assembly and spindle-length control.

8. Spindle assembly requires complete disassembly of spindle remnants from the previous cell cycle.

9. Force- and kinesin-8-dependent effects in the spatial regulation of fission yeast microtubule dynamics.

10. Time-lapse microscopy reveals unique roles for kinesins during anaphase in budding yeast.

Review 1. Emergent Properties of the Metaphase Spindle.

Review 2. Prime movers: the mechanochemistry of mitotic kinesins.

Review 3. Mitosis, microtubule dynamics and the evolution of kinesins.

4. A single-headed fission yeast myosin V transports actin in a tropomyosin-dependent manner.

5. Tubulin tyrosine nitration regulates microtubule organization in plant cells.