BACKGROUND: Inflammation is linked to adverse cardiovascular events, but its association with sudden cardiac death (SCD) has been controversial. Older subjects, who are at particular risk for SCD, were underrepresented in previous studies addressing this issue. OBJECTIVE: The purpose of this study was to study the association between inflammation and SCD in a community-based population of older adults. METHODS: In the Cardiovascular Health Study, 5806 and 5382 participants had measurements of C-reactive protein (CRP) and interleukin-6 (IL6), respectively, and were followed for up to 17 years. SCD risk as a function of baseline IL-6 and CRP was assessed in the overall population and in a group of participants without known prevalent cardiac disease. RESULTS: In univariate analyses, both IL-6 (hazard ratio [HR] 1.79 for 1+ log IL-6, 95% confidence interval [CI] 1.50-2.13; 5th vs 1st quintile HR 3.36, 95% CI 2.24-5.05) and CRP (HR 1.31 for 1+ log CRP, 95% CI 1.18-1.45; 5th vs 1st quintile HR 2.00, 95% CI 1.40-2.87) were associated with SCD risk. In covariate-adjusted analyses, accounting for baseline risk factors, incident myocardial infarction, and heart failure, the association with SCD risk persisted for IL-6 (HR 1.26 for 1+ log IL-6, 95% CI 1.02-1.56; 5th vs 1st quintile HR 1.63, 95% CI 1.03-2.56) but was significantly attenuated for CRP (HR 1.13 for 1+ log CRP, 95% CI 1.00-1.28; 5th vs 1st quintile HR 1.34, 95% CI 0.88-2.05). Similar findings were observed in participants without prevalent cardiac disease. CONCLUSION: Greater burden of inflammation, assessed by IL-6 levels, is associated with SCD risk beyond traditional risk factors, incident myocardial infarction, and heart failure.
BACKGROUND:Inflammation is linked to adverse cardiovascular events, but its association with sudden cardiac death (SCD) has been controversial. Older subjects, who are at particular risk for SCD, were underrepresented in previous studies addressing this issue. OBJECTIVE: The purpose of this study was to study the association between inflammation and SCD in a community-based population of older adults. METHODS: In the Cardiovascular Health Study, 5806 and 5382 participants had measurements of C-reactive protein (CRP) and interleukin-6 (IL6), respectively, and were followed for up to 17 years. SCD risk as a function of baseline IL-6 and CRP was assessed in the overall population and in a group of participants without known prevalent cardiac disease. RESULTS: In univariate analyses, both IL-6 (hazard ratio [HR] 1.79 for 1+ log IL-6, 95% confidence interval [CI] 1.50-2.13; 5th vs 1st quintile HR 3.36, 95% CI 2.24-5.05) and CRP (HR 1.31 for 1+ log CRP, 95% CI 1.18-1.45; 5th vs 1st quintile HR 2.00, 95% CI 1.40-2.87) were associated with SCD risk. In covariate-adjusted analyses, accounting for baseline risk factors, incident myocardial infarction, and heart failure, the association with SCD risk persisted for IL-6 (HR 1.26 for 1+ log IL-6, 95% CI 1.02-1.56; 5th vs 1st quintile HR 1.63, 95% CI 1.03-2.56) but was significantly attenuated for CRP (HR 1.13 for 1+ log CRP, 95% CI 1.00-1.28; 5th vs 1st quintile HR 1.34, 95% CI 0.88-2.05). Similar findings were observed in participants without prevalent cardiac disease. CONCLUSION: Greater burden of inflammation, assessed by IL-6 levels, is associated with SCD risk beyond traditional risk factors, incident myocardial infarction, and heart failure.
Authors: Wenjie Ma; Jason H Y Wu; Qianyi Wang; Rozenn N Lemaitre; Kenneth J Mukamal; Luc Djoussé; Irena B King; Xiaoling Song; Mary L Biggs; Joseph A Delaney; Jorge R Kizer; David S Siscovick; Dariush Mozaffarian Journal: Am J Clin Nutr Date: 2014-11-12 Impact factor: 7.045
Authors: Bruno B Lima; Muhammad Hammadah; Kobina Wilmot; Brad D Pearce; Amit Shah; Oleksiy Levantsevych; Belal Kaseer; Malik Obideen; Mohamad Mazen Gafeer; Jeong Hwan Kim; Samaah Sullivan; Tené T Lewis; Lei Weng; Lisa Elon; Lian Li; J Douglas Bremner; Paolo Raggi; Arshed Quyyumi; Viola Vaccarino Journal: Brain Behav Immun Date: 2018-08-30 Impact factor: 7.217
Authors: Robert J Lamberts; Marieke T Blom; Merel Wassenaar; Abdennasser Bardai; Frans S Leijten; Gerrit-Jan de Haan; Josemir W Sander; Roland D Thijs; Hanno L Tan Journal: Neurology Date: 2015-06-19 Impact factor: 9.910
Authors: Selcuk Adabag; Rachel R Huxley; Faye L Lopez; Lin Y Chen; Nona Sotoodehnia; David Siscovick; Rajat Deo; Suma Konety; Alvaro Alonso; Aaron R Folsom Journal: Heart Date: 2014-11-19 Impact factor: 5.994
Authors: Rajat Deo; Faye L Norby; Ronit Katz; Nona Sotoodehnia; Selcuk Adabag; Christopher R DeFilippi; Bryan Kestenbaum; Lin Y Chen; Susan R Heckbert; Aaron R Folsom; Richard A Kronmal; Suma Konety; Kristen K Patton; David Siscovick; Michael G Shlipak; Alvaro Alonso Journal: Circulation Date: 2016-08-19 Impact factor: 29.690
Authors: Michael G Silverman; Ashish Yeri; M Vinayaga Moorthy; Fernando Camacho Garcia; Neal A Chatterjee; Charlotte S A Glinge; Jacob Tfelt-Hansen; Ane M Salvador; Alexander R Pico; Ravi Shah; Christine M Albert; Saumya Das Journal: JACC Clin Electrophysiol Date: 2019-10-30