OBJECTIVE: Published studies on the prevalence of celiac disease in type 1 diabetes mellitus from the Arab World are scant. We aim to report the prevalence of celiac disease in Omani children with type 1 diabetes mellitus. METHODS: Children with type 1 diabetes mellitus were prospectively screened for celiac disease, at Sultan Qaboos University Hospital, Muscat, Oman over a period of one year (June 2011 - May 2012). Serum anti tissue transglutaminase IgA, endomysial IgA antibodies and total IgA were measured for screening of celiac disease. Children with positive anti-tissue transglutaminase and/or endomysial IgA antibodies underwent endoscopy. RESULTS: A total of 103 children with type 1 diabetes mellitus were initially included. Ten patients were lost to follow up. Ninety-three patients aged 2-17 years underwent screening for celiac disease. Sixteen patients had positive anti-tissue transglutaminase (17%). Fourteen patients underwent endoscopy with duodenal biopsies, while two were lost to follow-up. Five patients with positive anti-tissue transglutaminase had intestinal biopsy proven celiac disease. The prevalence of celiac disease is 5.5% in our cohort of children and adolescents with type 1 diabetes mellitus. CONCLUSIONS: The prevalence of celiac disease in Omani children and adolescents with type 1 diabetes mellitus is similar to the World's reported prevalence, but is less than that reported for Middle Eastern Arab children. To our knowledge, this is the first reported study on the prevalence of celiac disease in Omani children with type 1 diabetes mellitus.
OBJECTIVE: Published studies on the prevalence of celiac disease in type 1 diabetes mellitus from the Arab World are scant. We aim to report the prevalence of celiac disease in Omani children with type 1 diabetes mellitus. METHODS:Children with type 1 diabetes mellitus were prospectively screened for celiac disease, at Sultan Qaboos University Hospital, Muscat, Oman over a period of one year (June 2011 - May 2012). Serum anti tissue transglutaminase IgA, endomysial IgA antibodies and total IgA were measured for screening of celiac disease. Children with positive anti-tissue transglutaminase and/or endomysial IgA antibodies underwent endoscopy. RESULTS: A total of 103 children with type 1 diabetes mellitus were initially included. Ten patients were lost to follow up. Ninety-three patients aged 2-17 years underwent screening for celiac disease. Sixteen patients had positive anti-tissue transglutaminase (17%). Fourteen patients underwent endoscopy with duodenal biopsies, while two were lost to follow-up. Five patients with positive anti-tissue transglutaminase had intestinal biopsy proven celiac disease. The prevalence of celiac disease is 5.5% in our cohort of children and adolescents with type 1 diabetes mellitus. CONCLUSIONS: The prevalence of celiac disease in Omani children and adolescents with type 1 diabetes mellitus is similar to the World's reported prevalence, but is less than that reported for Middle Eastern Arab children. To our knowledge, this is the first reported study on the prevalence of celiac disease in Omani children with type 1 diabetes mellitus.
Entities:
Keywords:
Anti-tissue transglutaminase; Celiac Disease; Oman; Type 1 Diabetes Mellitus
Authors: D Hansen; F N Bennedbaek; L K Hansen; M Høier-Madsen; L S Hegedü; B B Jacobsen; S Husby Journal: Acta Paediatr Date: 2001-11 Impact factor: 2.299
Authors: P M Gillett; H R Gillett; D M Israel; D L Metzger; L Stewart; J P Chanoine; H J Freeman Journal: Can J Gastroenterol Date: 2001-05 Impact factor: 3.522
Authors: Saif Al-Yaarubi; Irfan Ullah; Sharef Waadallah Sharef; Azza Al Shidhani; Shaima Al Hanai; Rabaa Al Kalbani; Shamsa Al Jamoodi Journal: Oman Med J Date: 2014-03
Authors: Safa Ambusaidi; Al Manar Al Busaidi; Asma Al Salmani; Robin Davidson; Jalila Alshekaili; Mahmood Al Kindi; Rahma Al Kindi Journal: Sultan Qaboos Univ Med J Date: 2022-05-26
Authors: Ashraf El-Metwally; Paivi Toivola; Khalid AlAhmary; Salwa Bahkali; Ali AlKhathaami; Munira K AlSaqabi; Shatha A Al Ammar; Munazza Jawed; Saleh M Alosaimi Journal: Biomed Res Int Date: 2020-06-03 Impact factor: 3.411