STUDY OBJECTIVES: To determine rapid eye movement (REM) sleep phase preference in a crepuscular mammal (Octodon degus) by challenging the specific REM sleep homeostatic response during the diurnal and nocturnal anticrepuscular rest phases. DESIGN: We have investigated REM sleep rebound, recovery, and documented REM sleep propensity measures during and after diurnal and nocturnal selective REM sleep deprivations. SUBJECTS: Nine male wild-captured O. degus prepared for polysomnographic recordings. INTERVENTIONS: Animals were recorded during four consecutive baseline and two separate diurnal or nocturnal deprivation days, under a 12:12 light-dark schedule. Three-h selective REM sleep deprivations were performed, starting at midday (zeitgeber time 6) or midnight (zeitgeber time 18). MEASUREMENTS AND RESULTS: Diurnal and nocturnal REM sleep deprivations provoked equivalent amounts of REM sleep debt, but a consistent REM sleep rebound was found only after nocturnal deprivation. The nocturnal rebound was characterized by a complete recovery of REM sleep associated with an augment in REM/total sleep time ratio and enhancement in REM sleep episode consolidation. CONCLUSIONS: Our results support the notion that the circadian system actively promotes REM sleep. We propose that the sleep-wake cycle of O. degus is modulated by a chorus of circadian oscillators with a bimodal crepuscular modulation of arousal and a unimodal promotion of nocturnal REM sleep
STUDY OBJECTIVES: To determine rapid eye movement (REM) sleep phase preference in a crepuscular mammal (Octodon degus) by challenging the specific REM sleep homeostatic response during the diurnal and nocturnal anticrepuscular rest phases. DESIGN: We have investigated REM sleep rebound, recovery, and documented REM sleep propensity measures during and after diurnal and nocturnal selective REM sleep deprivations. SUBJECTS: Nine male wild-captured O. degus prepared for polysomnographic recordings. INTERVENTIONS: Animals were recorded during four consecutive baseline and two separate diurnal or nocturnal deprivation days, under a 12:12 light-dark schedule. Three-h selective REM sleep deprivations were performed, starting at midday (zeitgeber time 6) or midnight (zeitgeber time 18). MEASUREMENTS AND RESULTS: Diurnal and nocturnal REM sleep deprivations provoked equivalent amounts of REM sleep debt, but a consistent REM sleep rebound was found only after nocturnal deprivation. The nocturnal rebound was characterized by a complete recovery of REM sleep associated with an augment in REM/total sleep time ratio and enhancement in REM sleep episode consolidation. CONCLUSIONS: Our results support the notion that the circadian system actively promotes REM sleep. We propose that the sleep-wake cycle of O. degus is modulated by a chorus of circadian oscillators with a bimodal crepuscular modulation of arousal and a unimodal promotion of nocturnal REM sleep
Entities:
Keywords:
Octodon degus; REM sleep; REM sleep homeostasis; REM sleep rebound; crepuscular chronotype
Authors: Linda A W Verhagen; Paul Pévet; Michel Saboureau; Bruno Sicard; Béatrice Nesme; Bruno Claustrat; Ruud M Buijs; Andries Kalsbeek Journal: Brain Res Date: 2004-01-09 Impact factor: 3.252
Authors: G H Jacobs; J B Calderone; J A Fenwick; K Krogh; G A Williams Journal: J Comp Physiol A Neuroethol Sens Neural Behav Physiol Date: 2003-04-05 Impact factor: 1.836
Authors: Esther Werth; Kimberly A Cote; Eva Gallmann; Alexander A Borbély; Peter Achermann Journal: Am J Physiol Regul Integr Comp Physiol Date: 2002-08 Impact factor: 3.619