AIMS: Emerging data have indicated unexpected complexity in the regulation of vascular and bone calcification. In particular, several recent studies have challenged the concept of a universally positive relationship between body morphology [weight, height, body mass index (BMI), body surface area (BSA)] and the extent of vascular calcification. We sought to clarify these discrepancies and investigated the relationship between index lesion coronary artery calcification (CAC) and body morphology in patients undergoing percutaneous coronary intervention (PCI) using three-dimensional intravascular ultrasound (IVUS). METHODS AND RESULTS: We analysed CAC in patients who underwent PCI with pre-intervention IVUS imaging. The main outcome measure was the calcium index (CalcIndex); a three-dimensional IVUS-derived measure of total calcification per obstructive coronary lesion. A total of 346 patients (65.3 ± 10.6 years; 29.5% females) underwent PCI with IVUS-based CAC assessment. CalcIndex was categorized as zero-low (0-0.1399; n = 152) or intermediate-high (0.1400-1.2541; n = 194). All measures of body morphology were lower in patients with intermediate-high CalcIndex (height, P = 0.024; weight, P = 0.008; BMI, P = 0.064; BSA, P = 0.005). In adjusted multivariable models, weight and BSA were independent inverse predictors of intermediate-high CalcIndex [weight: odds ratio (OR) 0.986, P = 0.017; BSA: OR 0.323, P = 0.012] while CalcIndex also trended towards an inverse association with both height (P = 0.068) and BMI (P = 0.064). These independent inverse associations were consistent across multiple clinical subgroups, including stratification by age, race, gender, diabetes, and renal impairment. CONCLUSION: Using three-dimensional IVUS to assess vascular calcification, these data confirm an independent, inverse relationship between body size and index lesion CAC in patients with obstructive coronary artery disease.
AIMS: Emerging data have indicated unexpected complexity in the regulation of vascular and bone calcification. In particular, several recent studies have challenged the concept of a universally positive relationship between body morphology [weight, height, body mass index (BMI), body surface area (BSA)] and the extent of vascular calcification. We sought to clarify these discrepancies and investigated the relationship between index lesion coronary artery calcification (CAC) and body morphology in patients undergoing percutaneous coronary intervention (PCI) using three-dimensional intravascular ultrasound (IVUS). METHODS AND RESULTS: We analysed CAC in patients who underwent PCI with pre-intervention IVUS imaging. The main outcome measure was the calcium index (CalcIndex); a three-dimensional IVUS-derived measure of total calcification per obstructive coronary lesion. A total of 346 patients (65.3 ± 10.6 years; 29.5% females) underwent PCI with IVUS-based CAC assessment. CalcIndex was categorized as zero-low (0-0.1399; n = 152) or intermediate-high (0.1400-1.2541; n = 194). All measures of body morphology were lower in patients with intermediate-high CalcIndex (height, P = 0.024; weight, P = 0.008; BMI, P = 0.064; BSA, P = 0.005). In adjusted multivariable models, weight and BSA were independent inverse predictors of intermediate-high CalcIndex [weight: odds ratio (OR) 0.986, P = 0.017; BSA: OR 0.323, P = 0.012] while CalcIndex also trended towards an inverse association with both height (P = 0.068) and BMI (P = 0.064). These independent inverse associations were consistent across multiple clinical subgroups, including stratification by age, race, gender, diabetes, and renal impairment. CONCLUSION: Using three-dimensional IVUS to assess vascular calcification, these data confirm an independent, inverse relationship between body size and index lesion CAC in patients with obstructive coronary artery disease.
Entities:
Keywords:
Body surface area; Obesity; Vascular calcification; Weight
Authors: Duk-Hee Lee; Michael W Steffes; Myron Gross; Kyong Park; Paul Holvoet; Catarina I Kiefe; Cora E Lewis; David R Jacobs Journal: Am J Epidemiol Date: 2010-06-02 Impact factor: 4.897
Authors: Sammy Elmariah; Joseph A C Delaney; Kevin D O'Brien; Matthew J Budoff; Jens Vogel-Claussen; Valentin Fuster; Richard A Kronmal; Jonathan L Halperin Journal: J Am Coll Cardiol Date: 2010-11-16 Impact factor: 24.094
Authors: Michael H Criqui; Aruna Kamineni; Matthew A Allison; Joachim H Ix; Jeffrey J Carr; Mary Cushman; Robert Detrano; Wendy Post; Nathan D Wong Journal: Arterioscler Thromb Vasc Biol Date: 2010-09-02 Impact factor: 8.311
Authors: Tochi M Okwuosa; Philip Greenland; Susan G Lakoski; Hongyan Ning; Joseph Kang; Roger S Blumenthal; Moyses Szklo; John R Crouse; Joao A C Lima; Kiang Liu; Donald M Lloyd-Jones Journal: Am J Cardiol Date: 2011-03-15 Impact factor: 2.778
Authors: A E Odink; A van der Lugt; A Hofman; M G M Hunink; M M B Breteler; G P Krestin; J C M Witteman Journal: J Hum Hypertens Date: 2009-06-04 Impact factor: 3.012
Authors: Alina G van der Giessen; Frank J H Gijsen; Jolanda J Wentzel; Pushpa M Jairam; Theo van Walsum; Lisan A E Neefjes; Nico R Mollet; Wiro J Niessen; Frans N van de Vosse; Pim J de Feyter; Antonius F W van der Steen Journal: Int J Cardiovasc Imaging Date: 2010-07-03 Impact factor: 2.357
Authors: Marco Canepa; Pietro Ameri; Majd AlGhatrif; Gabriele Pestelli; Yuri Milaneschi; James B Strait; Francesco Giallauria; Giorgio Ghigliotti; Claudio Brunelli; Edward G Lakatta; Luigi Ferrucci Journal: Atherosclerosis Date: 2014-05-08 Impact factor: 5.162