Luisa Lázaro1, Susana Andrés, Anna Calvo, Clàudia Cullell, Elena Moreno, M Teresa Plana, Carles Falcón, Núria Bargalló, Josefina Castro-Fornieles. 1. Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clínic Universitari, Barcelona, Spain; IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain; Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.
Abstract
OBJECTIVE: The aim of this study was to determine whether treated, weight-stabilized adolescents with anorexia nervosa (AN) present brain volume differences in comparison with healthy controls. METHOD: Thirty-five adolescents with weight-recovered AN and 17 healthy controls were assessed by means of psychopathology scales and magnetic resonance imaging. Axial three-dimensional T1-weighted images were obtained in a 1.5 Tesla scanner and analyzed using optimized voxel-based morphometry (VBM). RESULTS: There were no significant differences between controls and weight-stabilized AN patients with regard to global volumes of either gray or white brain matter, or in the regional VBM study. Differences were not significant between patients with psychopharmacological treatment and without, between those with amenorrhea and without, as well as between patients with restrictive versus purgative AN. DISCUSSION: The present findings reveal no global or regional gray or white matter abnormalities in this sample of adolescents following weight restoration.
OBJECTIVE: The aim of this study was to determine whether treated, weight-stabilized adolescents with anorexia nervosa (AN) present brain volume differences in comparison with healthy controls. METHOD: Thirty-five adolescents with weight-recovered AN and 17 healthy controls were assessed by means of psychopathology scales and magnetic resonance imaging. Axial three-dimensional T1-weighted images were obtained in a 1.5 Tesla scanner and analyzed using optimized voxel-based morphometry (VBM). RESULTS: There were no significant differences between controls and weight-stabilized AN patients with regard to global volumes of either gray or white brain matter, or in the regional VBM study. Differences were not significant between patients with psychopharmacological treatment and without, between those with amenorrhea and without, as well as between patients with restrictive versus purgative AN. DISCUSSION: The present findings reveal no global or regional gray or white matter abnormalities in this sample of adolescents following weight restoration.
Authors: Esther Via; Andrew Zalesky; Isabel Sánchez; Laura Forcano; Ben J Harrison; Jesús Pujol; Fernando Fernández-Aranda; José Manuel Menchón; Carles Soriano-Mas; Narcís Cardoner; Alex Fornito Journal: J Psychiatry Neurosci Date: 2014-11 Impact factor: 6.186
Authors: C Christoph Schultz; Gerd Wagner; Feliberto de la Cruz; Sandy Berger; Jürgen R Reichenbach; Heinrich Sauer; Karl J Bär Journal: Eur Arch Psychiatry Clin Neurosci Date: 2015-12-17 Impact factor: 5.270
Authors: Josefina Castro-Fornieles; Elena de la Serna; Anna Calvo; José Pariente; Susana Andrés-Perpiña; Maria Teresa Plana; Sonia Romero; Itziar Flamarique; Miguel Gárriz; Núria Bargalló Journal: Eur Arch Psychiatry Clin Neurosci Date: 2019-03-07 Impact factor: 5.270