AIM: Exercise may induce an inflammatory response that may lead to changes in iron metabolism. The aim of this study was to examine the relationship between the inflammation induced by a 100 km run and the level of hepcidin, which is a hormone regulating iron metabolism. METHODS: Six males, age 44.5±13.5 years, running 100 km. SETTING: the CRP protein, IL-6 and leucocyte count were measured as an index of inflammation. RESULTS: A 100 km run caused a progressive increase in blood IL-6 concentration, which reached the highest values after 75 km. Furthermore, an increase in levels of CRP, a marker of inflammation, was observed after the 100 km run and continued to increase after a 14 h recovery period. Leucocyte number and markers of muscle damage were significantly elevated after the 100 km run. This was accompanied by a decrease in transferrin saturation and an increase in blood haemoglobin and ferritin. Despite all these changes, the 100 km race did not affect blood hepcidin concentration either during the run or after a 14 h recovery period. CONCLUSION: The study shows that a 100 km run induces an inflammatory response but does not trigger changes in the blood hepcidin level. Thus it can be concluded that changes in IL-6 are not sufficient to increase the blood hepcidin level in runners.
AIM: Exercise may induce an inflammatory response that may lead to changes in iron metabolism. The aim of this study was to examine the relationship between the inflammation induced by a 100 km run and the level of hepcidin, which is a hormone regulating iron metabolism. METHODS: Six males, age 44.5±13.5 years, running 100 km. SETTING: the CRP protein, IL-6 and leucocyte count were measured as an index of inflammation. RESULTS: A 100 km run caused a progressive increase in blood IL-6 concentration, which reached the highest values after 75 km. Furthermore, an increase in levels of CRP, a marker of inflammation, was observed after the 100 km run and continued to increase after a 14 h recovery period. Leucocyte number and markers of muscle damage were significantly elevated after the 100 km run. This was accompanied by a decrease in transferrin saturation and an increase in blood haemoglobin and ferritin. Despite all these changes, the 100 km race did not affect blood hepcidin concentration either during the run or after a 14 h recovery period. CONCLUSION: The study shows that a 100 km run induces an inflammatory response but does not trigger changes in the blood hepcidin level. Thus it can be concluded that changes in IL-6 are not sufficient to increase the blood hepcidin level in runners.
Authors: Edilberto S Barros; Dahan C Nascimento; Jonato Prestes; Otávio T Nóbrega; Claúdio Córdova; Fernando Sousa; Daniel A Boullosa Journal: Front Physiol Date: 2017-10-17 Impact factor: 4.566
Authors: Katarzyna Kasprowicz; Wojciech Ratkowski; Wojciech Wołyniec; Mariusz Kaczmarczyk; Konrad Witek; Piotr Żmijewski; Marcin Renke; Zbigniew Jastrzębski; Thomas Rosemann; Pantelis T Nikolaidis; Beat Knechtle Journal: Int J Environ Res Public Health Date: 2020-04-24 Impact factor: 3.390
Authors: Maja Tomczyk; Jakub Kortas; Damian Flis; Barbara Kaczorowska-Hac; Agata Grzybkowska; Andzelika Borkowska; Ewa Lewicka; Alicja Dabrowska-Kugacka; Jędrzej Antosiewicz Journal: Int J Environ Res Public Health Date: 2020-04-17 Impact factor: 3.390
Authors: Anna Czajkowska; Jadwiga Ambroszkiewicz; Anna Mróz; Katarzyna Witek; Dariusz Nowicki; Łukasz Małek Journal: Int J Environ Res Public Health Date: 2020-06-16 Impact factor: 3.390
Authors: Martina Zügel; Gunnar Treff; Jürgen M Steinacker; Benjamin Mayer; Kay Winkert; Uwe Schumann Journal: Front Physiol Date: 2020-01-21 Impact factor: 4.566