Literature DB >> 23902828

Synthesis of polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.

Marion Thévenin1, Sylviane Thoret, Philippe Grellier, Joëlle Dubois.   

Abstract

A series of polysubstituted benzofuran derivatives was easily and rapidly prepared using a tandem Sonogashira coupling/cyclization reaction. Subsequent acylation afforded a small library of 39 new compounds that were assayed in cellulo on Plasmodium falciparum and Trypanosoma brucei parasites. Some of them exhibited good inhibitory activity on T. brucei proliferation.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Antiparasitic; Benzofurans; P. falciparum; Sonogashira coupling reaction; T. brucei

Mesh：

Substances：

Year:  2013        PMID： 23902828     DOI： 10.1016/j.bmc.2013.07.002

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  10 in total

Review 1.  Natural source, bioactivity and synthesis of benzofuran derivatives.

Authors:  Yu-Hang Miao; Yu-Heng Hu; Jie Yang; Teng Liu; Jie Sun; Xiao-Jing Wang
Journal:  RSC Adv       Date:  2019-09-02       Impact factor: 4.036

2.  Synthesis of poly-functionalized benzofurans via one-pot domino oxidation/[3+2] cyclization reactions of a hydroquinone ester and ynamides.

Authors:  Dongxin Zhang; Jingjing Man; Yan Chen; Lei Yin; Junchao Zhong; Qian-Feng Zhang
Journal:  RSC Adv       Date:  2019-04-25       Impact factor: 4.036

Review 3.  Last Decade of Unconventional Methodologies for the Synthesis of Substituted Benzofurans.

Authors:  Lucia Chiummiento; Rosarita D'Orsi; Maria Funicello; Paolo Lupattelli
Journal:  Molecules       Date:  2020-05-16       Impact factor: 4.411

4.  Synthesis, Evaluation for Cytotoxicity and Molecular Docking Studies of Benzo[c]furan-Chalcones for Potential to Inhibit Tubulin Polymerization and/or EGFR-Tyrosine Kinase Phosphorylation.

Authors:  Malose J Mphahlele; Marole M Maluleka; Nishal Parbhoo; Sibusiso T Malindisa
Journal:  Int J Mol Sci       Date:  2018-08-28       Impact factor: 5.923

5.  Crystal structures of butyl 2-amino-5-hy-droxy-4-(4-nitro-phen-yl)benzo-furan-3-carboxyl-ate and 2-meth-oxy-ethyl 2-amino-5-hy-droxy-4-(4-nitro-phen-yl)benzo-furan-3-carboxyl-ate.

Authors:  Rosita Diana; Angela Tuzi; Barbara Panunzi; Antonio Carella; Ugo Caruso
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2019-05-24

6.  Protein Binding of Benzofuran Derivatives: A CD Spectroscopic and In Silico Comparative Study of the Effects of 4-Nitrophenyl Functionalized Benzofurans and Benzodifurans on BSA Protein Structure.

Authors:  Pasqualina Liana Scognamiglio; Caterina Vicidomini; Francesco Fontanella; Claudio De Stefano; Rosanna Palumbo; Giovanni N Roviello
Journal:  Biomolecules       Date:  2022-02-05

7.  Transition-metal-free base catalyzed intramolecular cyclization of 2-ynylphenols for efficient and facile synthesis of 2-substituted benzo[b]furans.

Authors:  Yong Liu; Tao Lu; Wei-Fang Tang; Jian Gao
Journal:  RSC Adv       Date:  2018-08-10       Impact factor: 3.361

8.  CD, UV, and In Silico Insights on the Effect of 1,3-Bis(1'-uracilyl)-2-propanone on Serum Albumin Structure.

Authors:  Francesca Greco; Andrea Patrizia Falanga; Monica Terracciano; Carlotta D'Ambrosio; Gennaro Piccialli; Giorgia Oliviero; Giovanni Nicola Roviello; Nicola Borbone
Journal:  Biomolecules       Date:  2022-08-03

9.  Synthesis and 2D-QSAR Study of Active Benzofuran-Based Vasodilators.

Authors:  Nagy M Khalifa; Aladdin M Srour; Somaia S Abd El-Karim; Dalia O Saleh; Mohamed A Al-Omar
Journal:  Molecules       Date:  2017-10-26       Impact factor: 4.411

10.  Benzofuran pyran hybrid prevents glucocorticoid induced osteoporosis in mice via modulation of canonical Wnt/β-catenin signaling.

Authors:  Ashish Kumar Tripathi; Divya Rai; Priyanka Kothari; Pragati Kushwaha; Koneni V Sashidhara; Ritu Trivedi
Journal:  Apoptosis       Date:  2022-02-02       Impact factor: 5.561
  10 in total

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