OBJECTIVE: To compare the original (1997) and revised (2009) versions of World Health Organization guidelines for dengue patients METHODS: Adult patients with a positive dengue Immunoglobulin M serology, and a diagnosis of dengue were included in the study at Aga Khan University Hospital during a three-year period from January 2005 to December 2007. Data related to these dengue patients was collected from their medical records. Guidelines were then applied by the research assistant and correlation among these guidelines was computed. SPSS 19 was used for statistical analysis. RESULTS: A total of 612 patients were found with a diagnosis of dengue, but only 439 (71.73%) had a positive IgM. The median age of these 439 patients was 28 (interquartile range: 18) years and majority of them were males, 295 (67%). According to the 1997 guidelines, 383 (87%) patients were classified as having dengue, while according to the 2009 guidelines, all the 439 (100%) patients were classified with a dengue infection. Under WHO 1997, 21 (5.5%) cases were classified as dengue shock syndrome, while 2009 guidelines labelled 88 (20%) cases as severe dengue. There was a consensus on only 11 severe cases by both the guidelines, showing different results between the two. CONCLUSION: By using 2009 guidelines, a physician would classify more dengue patients as having severe disease.
OBJECTIVE: To compare the original (1997) and revised (2009) versions of World Health Organization guidelines for dengue patients METHODS: Adult patients with a positive dengue Immunoglobulin M serology, and a diagnosis of dengue were included in the study at Aga Khan University Hospital during a three-year period from January 2005 to December 2007. Data related to these dengue patients was collected from their medical records. Guidelines were then applied by the research assistant and correlation among these guidelines was computed. SPSS 19 was used for statistical analysis. RESULTS: A total of 612 patients were found with a diagnosis of dengue, but only 439 (71.73%) had a positive IgM. The median age of these 439 patients was 28 (interquartile range: 18) years and majority of them were males, 295 (67%). According to the 1997 guidelines, 383 (87%) patients were classified as having dengue, while according to the 2009 guidelines, all the 439 (100%) patients were classified with a dengue infection. Under WHO 1997, 21 (5.5%) cases were classified as dengue shock syndrome, while 2009 guidelines labelled 88 (20%) cases as severe dengue. There was a consensus on only 11 severe cases by both the guidelines, showing different results between the two. CONCLUSION: By using 2009 guidelines, a physician would classify more dengue patients as having severe disease.
Authors: Fabio Zanini; Makeda L Robinson; Derek Croote; Malaya Kumar Sahoo; Ana Maria Sanz; Eliana Ortiz-Lasso; Ludwig Luis Albornoz; Fernando Rosso; Jose G Montoya; Leslie Goo; Benjamin A Pinsky; Stephen R Quake; Shirit Einav Journal: Proc Natl Acad Sci U S A Date: 2018-12-07 Impact factor: 11.205
Authors: Makeda Robinson; Timothy E Sweeney; Rina Barouch-Bentov; Malaya Kumar Sahoo; Larry Kalesinskas; Francesco Vallania; Ana Maria Sanz; Eliana Ortiz-Lasso; Ludwig Luis Albornoz; Fernando Rosso; Jose G Montoya; Benjamin A Pinsky; Purvesh Khatri; Shirit Einav Journal: Cell Rep Date: 2019-01-29 Impact factor: 9.423
Authors: Jorge D Mello-Román; Julio C Mello-Román; Santiago Gómez-Guerrero; Miguel García-Torres Journal: Comput Math Methods Med Date: 2019-07-29 Impact factor: 2.238
Authors: Natasha D Durham; Aditi Agrawal; Eric Waltari; Derek Croote; Fabio Zanini; Mallorie Fouch; Edgar Davidson; Olivia Smith; Esteban Carabajal; John E Pak; Benjamin J Doranz; Makeda Robinson; Ana M Sanz; Ludwig L Albornoz; Fernando Rosso; Shirit Einav; Stephen R Quake; Krista M McCutcheon; Leslie Goo Journal: Elife Date: 2019-12-10 Impact factor: 8.140