| Literature DB >> 23899374 |
Haibin Mao1, Aijun Lin, Yang Tang, Yan Shi, Hongwen Hu, Yixiang Cheng, Chengjian Zhu.
Abstract
A new useful and effective chiral amine-catalyzed oxa- and aza-Michael-Michael cascade methodology for the construction of enantiomerically enriched indolinones spiro-fused with chromans or tetrahydroquinolines is reported. By employing suitable organocatalysts depending on the different Michael donors (Ar-OH/Ar-NHR), the processes offered excellent stereocontrol (dr >20:1, >99% ee) under mild conditions.Entities:
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Year: 2013 PMID： 23899374 DOI： 10.1021/ol401595g
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005