| Literature DB >> 23899041 |
Bernd Schmidt1, Martin Riemer, Manfred Karras.
Abstract
User-friendly protocols for the protecting group-free synthesis of 2,2'-biphenols via Suzuki-Miyaura coupling of o-halophenols and o-boronophenol are presented. The reactions proceed in water in the presence of simple additives such as K2CO3, KOH, KF, or TBAF and with commercially available Pd/C as precatalyst. Expensive or laboriously synthesized ligands or other additives are not required. In the case of bromophenols, efficient rate acceleration and short reaction times were accomplished by microwave irradiation.Entities:
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Year: 2013 PMID： 23899041 DOI： 10.1021/jo401398n
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354