AIM: The relevance of the cytidine diphosphate-choline and Rho GTPases pathways in the pathogenesis of cancer has been previously demonstrated. We investigate by a case-control association study if genetics variants in these pathways are associated with risk of developing lung cancer. METHODS: Thirty-seven tag SNPs were evaluated as risk factor of NSCLC in 897 cases and 904 controls. RESULTS: Six SNPs were nominally associated with lung cancer risk, which were not significant after the Bonferroni correction for multiple comparisons. No association was observed with the remaining 31 analyzed SNPs, neither it was found significant in haplotype frequencies. CONCLUSIONS: Although the implication of the two pathways investigated in our study in carcinogenesis is well established, our null results suggest that common genetic variants in CDP-choline and Rho GTPases-related genes are not risk factors for lung cancer.
AIM: The relevance of the cytidine diphosphate-choline and Rho GTPases pathways in the pathogenesis of cancer has been previously demonstrated. We investigate by a case-control association study if genetics variants in these pathways are associated with risk of developing lung cancer. METHODS: Thirty-seven tag SNPs were evaluated as risk factor of NSCLC in 897 cases and 904 controls. RESULTS: Six SNPs were nominally associated with lung cancer risk, which were not significant after the Bonferroni correction for multiple comparisons. No association was observed with the remaining 31 analyzed SNPs, neither it was found significant in haplotype frequencies. CONCLUSIONS: Although the implication of the two pathways investigated in our study in carcinogenesis is well established, our null results suggest that common genetic variants in CDP-choline and Rho GTPases-related genes are not risk factors for lung cancer.
Authors: Ana Ramírez de Molina; David Gallego-Ortega; Jacinto Sarmentero; Mónica Bañez-Coronel; Yolanda Martín-Cantalejo; Juan Carlos Lacal Journal: Cancer Res Date: 2005-07-01 Impact factor: 12.701
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Authors: Ana Ramírez de Molina; Jacinto Sarmentero-Estrada; Cristóbal Belda-Iniesta; Miquel Tarón; Victor Ramírez de Molina; Paloma Cejas; Marcin Skrzypski; David Gallego-Ortega; Javier de Castro; Enrique Casado; Miguel Angel García-Cabezas; Jose Javier Sánchez; Manuel Nistal; Rafael Rosell; Manuel González-Barón; Juan Carlos Lacal Journal: Lancet Oncol Date: 2007-10 Impact factor: 41.316
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