QUESTION: Does the distance covered during a 6-minute walk test predict risk of death or hospitalisation for cardiovascular reasons in men with stable heart failure over three years of follow-up? DESIGN: Prospective observational study. PARTICIPANTS: 243 men with stable systolic heart failure, with a mean age of 60 yr (SD 11) and left ventricular ejection fraction of 29% (SD 8). According to the New York Heart Association (NYHA) classification, 15% of the participants were in Class I, 44% in Class II, 37% in Class III, and 4% in class IV. OUTCOME MEASURES: The exercise capacity of participants was measured using the 6-minute walk test. The participants were followed up for at least three years in the case of survivors. The primary end-points of the survival analyses included cardiovascular death or urgent cardiovascular hospitalisation. RESULTS: During the 3-year follow-up, 44% of the participants died, and 69% died or required hospitalisation for cardiovascular reasons. A multivariate analysis showed that the shorter the distance covered in the 6-minute walk test, the greater the 1-year and 3-year mortality risk. Participants with a 6-minute walk test ≤ 468 m had a mortality hazard ratio of 3.22 (95% CI 1.17 to 8.86) at one year and 2.18 (95% CI 1.18 to 4.03) at three years. Multivariate analysis also showed that higher risk mortality or hospitalisation for cardiovascular reasons was predicted by a 6-minute walk distance ≤ 468m, with a hazard ratio of 2.77 (95% CI 1.30 to 5.88) at one year and 1.71 (95% CI 1.08 to 2.72) at three years. CONCLUSION: The 6-minute walk test distance constitutes an independent predictor of mortality and mortality or hospitalisation for cardiovascular reasons in men with stable systolic heart failure.
QUESTION: Does the distance covered during a 6-minute walk test predict risk of death or hospitalisation for cardiovascular reasons in men with stable heart failure over three years of follow-up? DESIGN: Prospective observational study. PARTICIPANTS: 243 men with stable systolic heart failure, with a mean age of 60 yr (SD 11) and left ventricular ejection fraction of 29% (SD 8). According to the New York Heart Association (NYHA) classification, 15% of the participants were in Class I, 44% in Class II, 37% in Class III, and 4% in class IV. OUTCOME MEASURES: The exercise capacity of participants was measured using the 6-minute walk test. The participants were followed up for at least three years in the case of survivors. The primary end-points of the survival analyses included cardiovascular death or urgent cardiovascular hospitalisation. RESULTS: During the 3-year follow-up, 44% of the participants died, and 69% died or required hospitalisation for cardiovascular reasons. A multivariate analysis showed that the shorter the distance covered in the 6-minute walk test, the greater the 1-year and 3-year mortality risk. Participants with a 6-minute walk test ≤ 468 m had a mortality hazard ratio of 3.22 (95% CI 1.17 to 8.86) at one year and 2.18 (95% CI 1.18 to 4.03) at three years. Multivariate analysis also showed that higher risk mortality or hospitalisation for cardiovascular reasons was predicted by a 6-minute walk distance ≤ 468m, with a hazard ratio of 2.77 (95% CI 1.30 to 5.88) at one year and 1.71 (95% CI 1.08 to 2.72) at three years. CONCLUSION: The 6-minute walk test distance constitutes an independent predictor of mortality and mortality or hospitalisation for cardiovascular reasons in men with stable systolic heart failure.
Authors: Andrew Sherwood; LaBarron K Hill; James A Blumenthal; Kirkwood F Adams; Nicola J Paine; Gary G Koch; Christopher M O'Connor; Kristy S Johnson; Alan L Hinderliter Journal: Am Heart J Date: 2017-07-12 Impact factor: 4.749
Authors: Grace J Wang; Pamela A Shaw; Raymond R Townsend; Amanda H Anderson; Dawei Xie; Xue Wang; Lisa C Nessel; Emile R Mohler; Stephen M Sozio; Bernard G Jaar; Jing Chen; Jackson Wright; Jonathan J Taliercio; Akinlolu Ojo; Ana C Ricardo; Eva Lustigova; Ronald M Fairman; Harold I Feldman; Bonnie Ky Journal: Ann Vasc Surg Date: 2016-05-20 Impact factor: 1.466
Authors: Giane A Ribeiro-Samora; Dayane Montemezzo; Danielle A G Pereira; Thaysa L Tagliaferri; Otávia A Vieira; Raquel R Britto Journal: Braz J Phys Ther Date: 2017-03-17 Impact factor: 3.377