BACKGROUND: Hypertrophic cardiomyopathy is an important cause of disability and death in patients of all ages. Egyptian children may differ from Western and Asian patients in the pattern of hypertrophy distribution, clinical manifestations, and risk factors. OBJECTIVES: The aim of our study was to report the clinical characteristics and outcomes of Egyptian children with hypertrophic cardiomyopathy studied over a 7-year duration and to determine whether the reported adult risk factors for sudden cardiac death are predictive of the outcome in these affected children. STUDY DESIGN AND METHODS: This retrospective study included 128 hypertrophic cardiomyopathy children. The data included personal history, family history, physical examination, baseline laboratory measurements, electrocardiogram, and Holter and echocardiographic results. Logistic regression analysis was used for the detection of risk factors of death. RESULTS: Fifty-one out of 128 patients died during the period of the study. Of the 51 deaths, 36 (70.5%) occurred in patients presenting before 1 year of age. Only eight patients had surgical intervention. Extreme left ventricular hypertrophy, that is, interventricular septal wall thickness or posterior wall thickness Z-score >6, sinus tachycardia, and supraventricular tachycardia were found to be independent risk factors for prediction of death in patients with hypertrophic cardiomyopathy. CONCLUSIONS: At our Egyptian tertiary care centre, hypertrophic cardiomyopathy has a relatively worse prognosis when compared with reports from Western and Asian series. Infants have a worse outcome than children presenting after the age of 1 year. A poorer prognosis in childhood hypertrophic cardiomyopathy is predicted by an extreme left ventricular hypertrophy, the presence of sinus tachycardia, and supraventricular tachycardia.
BACKGROUND:Hypertrophic cardiomyopathy is an important cause of disability and death in patients of all ages. Egyptian children may differ from Western and Asian patients in the pattern of hypertrophy distribution, clinical manifestations, and risk factors. OBJECTIVES: The aim of our study was to report the clinical characteristics and outcomes of Egyptian children with hypertrophic cardiomyopathy studied over a 7-year duration and to determine whether the reported adult risk factors for sudden cardiac death are predictive of the outcome in these affected children. STUDY DESIGN AND METHODS: This retrospective study included 128 hypertrophic cardiomyopathychildren. The data included personal history, family history, physical examination, baseline laboratory measurements, electrocardiogram, and Holter and echocardiographic results. Logistic regression analysis was used for the detection of risk factors of death. RESULTS: Fifty-one out of 128 patients died during the period of the study. Of the 51 deaths, 36 (70.5%) occurred in patients presenting before 1 year of age. Only eight patients had surgical intervention. Extreme left ventricular hypertrophy, that is, interventricular septal wall thickness or posterior wall thickness Z-score >6, sinus tachycardia, and supraventricular tachycardia were found to be independent risk factors for prediction of death in patients with hypertrophic cardiomyopathy. CONCLUSIONS: At our Egyptian tertiary care centre, hypertrophic cardiomyopathy has a relatively worse prognosis when compared with reports from Western and Asian series. Infants have a worse outcome than children presenting after the age of 1 year. A poorer prognosis in childhood hypertrophic cardiomyopathy is predicted by an extreme left ventricular hypertrophy, the presence of sinus tachycardia, and supraventricular tachycardia.
Authors: Jolanda van der Velden; Carolyn Y Ho; Jil C Tardiff; Iacopo Olivotto; Bjorn C Knollmann; Lucie Carrier Journal: Cardiovasc Res Date: 2015-01-28 Impact factor: 10.787
Authors: Jil C Tardiff; Lucie Carrier; Donald M Bers; Corrado Poggesi; Cecilia Ferrantini; Raffaele Coppini; Lars S Maier; Houman Ashrafian; Sabine Huke; Jolanda van der Velden Journal: Cardiovasc Res Date: 2015-01-29 Impact factor: 10.787
Authors: Felix W Friedrich; Hannieh Sotoud; Birgit Geertz; Silvio Weber; Frederik Flenner; Silke Reischmann; Thomas Eschenhagen; Lucie Carrier; Ali El-Armouche Journal: Int J Cardiol Heart Vasc Date: 2015-05-29
Authors: Gabrielle Norrish; Tao Ding; Ella Field; Elena Cervi; Lidia Ziółkowska; Iacopo Olivotto; Diala Khraiche; Giuseppe Limongelli; Aris Anastasakis; Robert Weintraub; Elena Biagini; Luca Ragni; Terrence Prendiville; Sophie Duignan; Karen McLeod; Maria Ilina; Adrián Fernández; Chiara Marrone; Regina Bökenkamp; Anwar Baban; Peter Kubus; Piers E F Daubeney; Georgia Sarquella-Brugada; Sergi Cesar; Sabine Klaassen; Tiina H Ojala; Vinay Bhole; Constancio Medrano; Orhan Uzun; Elspeth Brown; Ferran Gran; Gianfranco Sinagra; Francisco J Castro; Graham Stuart; Gabriele Vignati; Hirokuni Yamazawa; Roberto Barriales-Villa; Luis Garcia-Guereta; Satish Adwani; Katie Linter; Tara Bharucha; Pablo Garcia-Pavia; Ana Siles; Torsten B Rasmussen; Margherita Calcagnino; Caroline B Jones; Hans De Wilde; Toru Kubo; Tiziana Felice; Anca Popoiu; Jens Mogensen; Sujeev Mathur; Fernando Centeno; Zdenka Reinhardt; Sylvie Schouvey; Costas O'Mahony; Rumana Z Omar; Perry M Elliott; Juan Pablo Kaski Journal: Circ Arrhythm Electrophysiol Date: 2022-05-02