BACKGROUND: There are many cytokines, including TNF-α, TGFβ, PGF, and other factors contributing towards fibrogenesis, that play a role in the control of HBV infection. Among these, TNF-α is the most important cytokine in host immune response to viral infection. This study aimed to determine whether differences in the promoter region of the TNF-α gene may alter the outcomes of HBV infection. METHODS: Two polymorphisms of tumor necrosis factor-α (TNF-α) gene, -308 G/A (rs1800629) and -863 C/A (rs1800630), were analyzed by DNA sequence in the case-control sample using 171 chronic HBV-infected patients and 227 recovered HBV-infected controls. All subjects were unrelated southern Han Chinese. RESULTS: For TNF-α-308, healthy controls compared to HBV infection have a significantly higher allele A and GA genotype frequency. For TNF-α-863, no significant differences in allele or genotype frequencies between the case groups and the control group were observed. CONCLUSIONS: This study provides evidence of a positive association between HBV clearance and TNF-α-308A.
BACKGROUND: There are many cytokines, including TNF-α, TGFβ, PGF, and other factors contributing towards fibrogenesis, that play a role in the control of HBV infection. Among these, TNF-α is the most important cytokine in host immune response to viral infection. This study aimed to determine whether differences in the promoter region of the TNF-α gene may alter the outcomes of HBV infection. METHODS: Two polymorphisms of tumor necrosis factor-α (TNF-α) gene, -308 G/A (rs1800629) and -863 C/A (rs1800630), were analyzed by DNA sequence in the case-control sample using 171 chronic HBV-infectedpatients and 227 recovered HBV-infected controls. All subjects were unrelated southern Han Chinese. RESULTS: For TNF-α-308, healthy controls compared to HBV infection have a significantly higher allele A and GA genotype frequency. For TNF-α-863, no significant differences in allele or genotype frequencies between the case groups and the control group were observed. CONCLUSIONS: This study provides evidence of a positive association between HBV clearance and TNF-α-308A.
Authors: Karl S Lang; Philipp A Lang; Prashant V Shinde; Haifeng C Xu; Sathish Kumar Maney; Andreas Kloetgen; Sukumar Namineni; Yuan Zhuang; Nadine Honke; Namir Shaabani; Nicolas Bellora; Mareike Doerrenberg; Mirko Trilling; Vitaly I Pozdeev; Nico van Rooijen; Stefanie Scheu; Klaus Pfeffer; Paul R Crocker; Masato Tanaka; Sujitha Duggimpudi; Percy Knolle; Mathias Heikenwalder; Jürgen Ruland; Tak W Mak; Dirk Brenner; Aleksandra A Pandyra; Jessica I Hoell; Arndt Borkhardt; Dieter Häussinger Journal: J Virol Date: 2018-01-17 Impact factor: 5.103
Authors: Anna Woziwodzka; Magda Rybicka; Alicja Sznarkowska; Tomasz Romanowski; Marcin Dręczewski; Piotr Stalke; Krzysztof Piotr Bielawski Journal: Mol Genet Genomic Med Date: 2019-08-23 Impact factor: 2.183