PRIMARY OBJECTIVE: Development of depression after TBI is linked to poorer outcomes. The aim of this manuscript is to review evidence for the effectiveness of current treatments. RESEARCH DESIGN: Two meta-analyses were undertaken to examine the effectiveness of both pharmacological and non-pharmacological interventions for depression after mild TBI. METHOD AND PROCEDURES: PubMed, Medline, PsychInfo, Web of Science and Digital Dissertations were searched and 13 studies located. Meta Analyst Beta 3.13 was used to conduct analyses of pre- vs post-effects then to examine treatment group vs control group effects. MAIN OUTCOMES AND RESULTS: Studies using a pre-post design produced an overall effect size of 1.89 (95% CI = 1.20-2.58, p < 0.001), suggesting that treatments were effective; however, the overall effect for controlled trials was 0.46 (95% CI = -0.44-1.36, p < 0.001), which favoured the control rather than treatment groups. CONCLUSIONS: This study highlights the need for additional large well-controlled trials of effective treatments for depression post-TBI.
PRIMARY OBJECTIVE: Development of depression after TBI is linked to poorer outcomes. The aim of this manuscript is to review evidence for the effectiveness of current treatments. RESEARCH DESIGN: Two meta-analyses were undertaken to examine the effectiveness of both pharmacological and non-pharmacological interventions for depression after mild TBI. METHOD AND PROCEDURES: PubMed, Medline, PsychInfo, Web of Science and Digital Dissertations were searched and 13 studies located. Meta Analyst Beta 3.13 was used to conduct analyses of pre- vs post-effects then to examine treatment group vs control group effects. MAIN OUTCOMES AND RESULTS: Studies using a pre-post design produced an overall effect size of 1.89 (95% CI = 1.20-2.58, p < 0.001), suggesting that treatments were effective; however, the overall effect for controlled trials was 0.46 (95% CI = -0.44-1.36, p < 0.001), which favoured the control rather than treatment groups. CONCLUSIONS: This study highlights the need for additional large well-controlled trials of effective treatments for depression post-TBI.
Authors: Charles H Bombardier; Jesse R Fann; Evette J Ludman; Steven D Vannoy; Joshua R Dyer; Jason K Barber; Nancy R Temkin Journal: J Head Trauma Rehabil Date: 2017 Sep/Oct Impact factor: 2.710
Authors: Jesse R Fann; Charles H Bombardier; Nancy Temkin; Peter Esselman; Catherine Warms; Jason Barber; Sureyya Dikmen Journal: J Head Trauma Rehabil Date: 2017 Sep/Oct Impact factor: 2.710
Authors: Ana Luiza Zaninotto; Jessica Elias Vicentini; Felipe Fregni; Priscila Aparecida Rodrigues; Cibele Botelho; Mara Cristina Souza de Lucia; Wellingson Silva Paiva Journal: Front Psychiatry Date: 2016-06-14 Impact factor: 4.157