Literature DB >> 23893865

The Crosslink formation of 2'-OMe oligonucleotide containing 2-amino-6-vinylpurine protects mRNA from miRNA-mediated silencing.

Shinya Hagihara1, Wei-Chen Lin, Shuhei Kusano, Xiao-Guang Chao, Tsuneaki Hori, Shuhei Imoto, Fumi Nagatsugi.   

Abstract

Masking the miRNA binding site: Crosslink-forming oligonucleotide (CFO) was used for target gene-specific inhibition of microRNA (miRNA) functions. This method can interfere with specific miRNA-mRNA interactions by recognizing sequences unique to the 3'-UTR that are inherent in each mRNA.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  crosslinks; gene expression; mRNA; miRNA; oligonucleotides

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Year:  2013        PMID： 23893865     DOI： 10.1002/cbic.201300382

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  2 in total

1.  Stable duplex-linked antisense targeting miR-148a inhibits breast cancer cell proliferation.

Authors:  Sho Okumura; Yu Hirano; Yasuo Komatsu
Journal:  Sci Rep       Date:  2021-06-01       Impact factor: 4.379

2.  Crosslinking reactions of 4-amino-6-oxo-2-vinylpyrimidine with guanine derivatives and structural analysis of the adducts.

Authors:  Shuhei Kusano; Shogo Ishiyama; Sik Lok Lam; Tsukasa Mashima; Masato Katahira; Kengo Miyamoto; Misako Aida; Fumi Nagatsugi
Journal:  Nucleic Acids Res       Date:  2015-08-05       Impact factor: 16.971
  2 in total

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